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Diacerhein

diacerein

CAS: 13739-02-1

Molecular Formula: C19H12O8

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Diacerhein - Names and Identifiers

Name diacerein
Synonyms artrodar
DIACEREIN
diacerein
DIACERHEIN
Diacerhein
DIACETYL RHEIN
1,8-Diacetoxy-3-carboxyanthraquinone
1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE
4,5-Bis(acetyloxy)-9,10-dioxo-2-anthracenecarboxylic acid
9,10-dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylicacid
9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicacidiacetate
9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicaciddiacetate
4,5-bis(acetyloxy)-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
CAS 13739-02-1
EINECS 237-310-2
InChI InChI=1/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)
InChIKey TYNLGDBUJLVSMA-UHFFFAOYSA-N

Diacerhein - Physico-chemical Properties

Molecular FormulaC19H12O8
Molar Mass368.29
Density1.491±0.06 g/cm3(Predicted)
Melting Point217-2180C
Boling Point631.5±55.0 °C(Predicted)
Flash Point231.8°C
Water Solubility240μg/L at 25℃
Solubility Easily soluble in dimethyl sulfoxide and dimethyl acetamide; hardly soluble in water, methanol and chloroform.
Vapor Presure8.17E-17mmHg at 25°C
AppearanceOrange-yellow long needle crystal (orange crystal in acetone, yellow crystal in methanol)
ColorLight Yellow to Yellow
Merck14,2960
pKa3.01±0.20(Predicted)
Storage ConditionSealed in dry,Room Temperature
Refractive Index1.634
MDLMFCD00468030
UseThis product is an important inhibitor of osteoarthritis IL-1. Used for osteoarthritis

Diacerhein - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany3
RTECSCB8781000
HS Code29146990

Diacerhein - Reference Information

Immunosuppressive drugs Diacetate, also known as diacetyl dihydroanthracene carboxylic acid, 1, 8-diacetyl -3-carboxyl anthraquinone, daceruin, and ambidine, is a new interleukin (IL)-1 inhibitor, the chemical name is diacetyl rheoic acid, which is an anthraquinone compound, this product can induce cartilage formation, has analgesic, anti-inflammatory and antipyretic effects, can also significantly improve the joint function of patients with osteoarthritis, delay the course of disease, relieve pain, improve the quality of life of patients, and has good safety. It is mainly used in the treatment of osteoarthritis (OA) and plays an antibacterial role.
Solubility: easily soluble in dimethyl sulfoxide and dimethyl acetamide; hardly soluble in water, methanol and chloroform.
diacenine and its active metabolite rhein reduce the production and activity of IL-1β by inhibiting IL-1 converting enzyme. The mechanism of action includes:
1, inhibiting the synthesis of IL-1 in synovial tissue.
2, inhibit the expression of IL-1 receptor in chondrocytes.
3, inhibit the activity of IL-1.
4, inhibit the generation of metalloproteinases and peroxides such as collagenase and matrix lysin.
5, promote the synthesis of collagen and aminopolysaccharide.
6, inhibit the chemotaxis of leukocytes and stabilize lysosomes.
Diacetate does not change the epoxidase activity of kidneys and platelets, and does not inhibit prostaglandins and formation, so patients with prostaglandin-dependent renal dysfunction can tolerate it.
oral administration of 50mg,PPB is 99%,Tmax is 2.2 h,Cmax is 3.2 mg/L,AUC is 21.3 mg h/L, T1/2β is 4.3 h. Serving with food can increase the Tmax and AUC values of this product.
adverse reactions: diarrhea, abdominal pain and soft stool may occur in 50% patients.
effect diacerein and its metabolite rhein can inhibit the production and activity of urokinase-type plasminogen activator (u-PA), directly reduce osteoblast synthesis, reduce osteocalcin and promote bone mineralization.
use widely used in new liquid crystal polymers, high-strength fibers with excellent performance and engineering plastics
this product is an important inhibitor of osteoarthritis IL-1. Used for osteoarthritis
natural antioxidant has the effects of delaying aging, enhancing immunity, clearing sub-health state, restoring physical fitness, improving energy and body immunity, etc.
an interleukin-1β inhibitor, which is a slow-acting anthraquinone compound.
Last Update：2024-04-09 19:05:10
Diacerhein
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
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CAS: 13739-02-1
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CAS: 13739-02-1
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CAS: 13739-02-1
Tel: 18301782025
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Shanghai Worldyang Chemical Co.,Ltd.
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Hangzhou Verychem Science And Technology Co.Ltd
Product Name: Diacerein Request for quotation
CAS: 13739-02-1
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
Product List: View Catalog
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Diacerein Visit Supplier Webpage Request for quotation
CAS: 13739-02-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: diacerein Request for quotation
CAS: 13739-02-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Diacerein Visit Supplier Webpage Request for quotation
CAS: 13739-02-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: Diacerein Request for quotation
CAS: 13739-02-1
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
Hangzhou Verychem Science And Technology Co.Ltd
Product Name: Diacerein Request for quotation
CAS: 13739-02-1
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
Product List: View Catalog
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Diacerhein
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