Dicumoxane
coumetarol
CAS: 4366-18-1
Molecular Formula: C21H16O7
Dicumoxane - Names and Identifiers
| Name | coumetarol |
| Synonyms | Dicumoxane Dicoumoxyl Cumetharol coumetarol Cumethoxethan 3,3'-(2-Methoxyethylidene)bis(4-hydroxycoumarin) 2-hydroxy-3-[1-(2-hydroxy-4-keto-chromen-3-yl)-2-methoxy-ethyl]chromone 2-hydroxy-3-[1-(2-hydroxy-4-oxochromen-3-yl)-2-methoxyethyl]chromen-4-one 2-hydroxy-3-[1-(2-hydroxy-4-oxo-chromen-3-yl)-2-methoxy-ethyl]chromen-4-one |
| CAS | 4366-18-1 |
| EINECS | 2244551 |
Dicumoxane - Physico-chemical Properties
| Molecular Formula | C21H16O7 |
| Molar Mass | 380.35 |
| Density | 1.514±0.06 g/cm3(Predicted) |
| Melting Point | 156-157° |
| Boling Point | 639.9±55.0 °C(Predicted) |
| pKa | 4.20±1.00(Predicted) |
| In vitro study | Coumetarol (Dicumoxane), an oral anticoagulant, is active in both models. The vitamin K antagonist Coumetarol is effective in both models after oral treatment but inhibits the thrombus formation more strongly in the arterio-venous shunt model. Treatment with the vitamin K antagonist Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments the coagulation time as measured by the Thrombotest is prolonged to the same extent. |
Dicumoxane - Risk and Safety
| UN IDs | 2811 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
Dicumoxane - References
| biological activity | Coumetarol (Dicumoxane) is a vitamin K antagonist. |
| Target | vitamin K |
Last Update：2024-04-09 20:45:29
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Product Name: coumetarol Request for quotationCAS: 4366-18-1
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
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