Diflorasone
Diflorasone
CAS: 2557-49-5
Molecular Formula: C22H28F2O5
Diflorasone - Names and Identifiers
Diflorasone - Physico-chemical Properties
| Molecular Formula | C22H28F2O5 |
| Molar Mass | 410.46 |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Melting Point | 228-239°C |
| Boling Point | 569.8±50.0 °C(Predicted) |
| Flash Point | 298.4°C |
| Solubility | Methanol (Slightly) |
| Vapor Presure | 2.33E-15mmHg at 25°C |
| Appearance | A white to pink crystal |
| Color | Off-White to Pale Yellow |
| pKa | 11.98±0.70(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.579 |
Diflorasone - Reference
| Reference Show more | 1. Zhang Jing, Yan Xiaohong, Lai Junmin, et al. Simultaneous Determination of Three Glucocorticoids Illegally Added to Standards in Cosmetics by Liquid Chromatography-Tandem Mass Spectrometry [J]. Today's Pharmacy, 2018, 28(11):19-21. |
Diflorasone - Reference Information
| introduction | diflorasone, Chinese alias diflorasone, diflorasone diflorasone cream, sokang, molecular formula: C22H28F2O5, molecular weight: 410.45. Diflurazone is a corticosteroid preparation, which has anti-inflammatory, anti-pruritic, immunosuppressive and vasoconstrictive effects. The pharmacological effects after external use are similar to betamethasone and its derivatives. It is suitable for corticosteroid hormone treatment. Effective various skin diseases can reduce inflammation and itching symptoms. Mainly used for psoriasis, contact dermatitis, numismatic eczema, chronic hand and foot dermatitis, sweat herpes, etc. Apply to the affected area twice a day. |
| Preparation | The solution prepared by potassium carbonate (0.7g) and water (7ml) is added to the suspension of difluoropone 21-acetate (1.4g) in methanol (15ml) under stirring, and the solution is concentrated in vacuum for 3 hours, and the residue is diluted with water. The resulting suspension was filtered to obtain diflorazon, which was washed with water and dried. |
| biological activity | Diflorasone is an agonist of corticosteroid receptor (corticosteroid hormone receptor) and has anti-inflammatory and immunosuppressive properties. Diflorasone diffuses into the cell through the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. It is Diflorasone used for the study of skin diseases such as eczema and psoriasis. |
| target | IC50: corticosteroid hormone receptor |
Last Update：2024-04-09 21:04:16
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Product Name: Diflorasone Visit Supplier Webpage Request for quotationCAS: 2557-49-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Diflorasone Visit Supplier Webpage Request for quotationCAS: 2557-49-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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