Difluorophenylpiperazine
Difluorophenylpiperazine
CAS: 115761-79-0
Molecular Formula: C10H12F2N2
Difluorophenylpiperazine - Names and Identifiers
| Name | Difluorophenylpiperazine |
| Synonyms | RARECHEM AH CK 0086 Difluorophenylpiperazine difluorophenylpiperazine -(2,4-Difluorophenyl)piperazine 1-(2,4-Difluorophenyl)piperazine 1-(2,4-DIFLUOROPHENYL)PIPERAZINE Piperazine, 1-(2,4-difluorophenyl)- 4-(2,4-difluorophenyl)piperazin-1-ium |
| CAS | 115761-79-0 |
| EINECS | 201-344-6 |
| InChI | InChI=1/C10H12F2N2/c11-8-1-2-10(9(12)7-8)14-5-3-13-4-6-14/h1-2,7,13H,3-6H2/p+1 |
Difluorophenylpiperazine - Physico-chemical Properties
| Molecular Formula | C10H12F2N2 |
| Molar Mass | 198.21 |
| Density | 1.192±0.06 g/cm3(Predicted) |
| Melting Point | 74-76 |
| Boling Point | 100 °C (0.37505 mmHg) |
| Flash Point | 108-111°C/0.2mm |
| Vapor Presure | 0.00175mmHg at 25°C |
| Appearance | White crystal or crystalline powder |
| BRN | 8620369 |
| pKa | 8.75±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Air Sensitive |
| MDL | MFCD00082588 |
Difluorophenylpiperazine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN2928 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | II |
Difluorophenylpiperazine - Introduction
Difluorophenylpiperazine is an organic compound with the chemical formula C10H8F2N2. It is a white crystalline solid.
Difluorophenylpiperazine has good stability and thermal stability, and is soluble in some organic solvents, such as methanol, ethanol and dimethylformamide. It is slowly soluble in toluene, but insoluble in water.
One of the main uses of difluorophenyl piperazine is as a pharmaceutical intermediate for the synthesis of some pharmaceutical compounds. It can also be used as a reagent in organic synthesis, playing a catalytic or changing role in the reaction process with other compounds.
The method for preparing difluorophenyl piperazine is usually generated by reacting difluorobenzoyl chloride and pyrazinidine. First, difluorobenzoyl chloride is added into the pyrazinica solution, and the reaction is stirred at a relatively low temperature. Then, the reaction solution undergoes distillation, filtration, crystallization and other steps to finally obtain difluorophenyl piperazine.
Regarding the safety information of difluorophenyl piperazine, attention should be paid to its irritation to the eyes, skin and respiratory system, and direct contact should be avoided. Care should be taken to prevent contact with oxidants and strong acids during use and storage. At the same time, it is necessary to follow the laboratory's safe operating procedures and wear appropriate personal protective equipment.
Difluorophenylpiperazine has good stability and thermal stability, and is soluble in some organic solvents, such as methanol, ethanol and dimethylformamide. It is slowly soluble in toluene, but insoluble in water.
One of the main uses of difluorophenyl piperazine is as a pharmaceutical intermediate for the synthesis of some pharmaceutical compounds. It can also be used as a reagent in organic synthesis, playing a catalytic or changing role in the reaction process with other compounds.
The method for preparing difluorophenyl piperazine is usually generated by reacting difluorobenzoyl chloride and pyrazinidine. First, difluorobenzoyl chloride is added into the pyrazinica solution, and the reaction is stirred at a relatively low temperature. Then, the reaction solution undergoes distillation, filtration, crystallization and other steps to finally obtain difluorophenyl piperazine.
Regarding the safety information of difluorophenyl piperazine, attention should be paid to its irritation to the eyes, skin and respiratory system, and direct contact should be avoided. Care should be taken to prevent contact with oxidants and strong acids during use and storage. At the same time, it is necessary to follow the laboratory's safe operating procedures and wear appropriate personal protective equipment.
Last Update：2024-04-09 21:54:55
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