Disopyramide
Disopyramide
CAS: 3737-09-5
Molecular Formula: C21H29N3O
Disopyramide - Names and Identifiers
Disopyramide - Physico-chemical Properties
| Molecular Formula | C21H29N3O |
| Molar Mass | 339.48 |
| Density | 1.0779 (rough estimate) |
| Melting Point | 94.5-950C |
| Boling Point | 475.43°C (rough estimate) |
| Water Solubility | 6.17mg/L(22.5 ºC) |
| Solubility | Soluble in DMSO (25 mg/ml) and Ethanol (>35 mg/mL) |
| Appearance | solid |
| Color | White |
| Merck | 14,3360 |
| pKa | 10.2; also reported as 10.45(at 25℃) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Refractive Index | 1.6300 (estimate) |
| In vitro study | HERG tail currents recorded at -40 mV following test pulses to +30 mV were inhibited in a dose-dependent fashion by Disopyramide concentrations within the clinical range (IC 50 =7.23 μM). |
Disopyramide - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| WGK Germany | 3 |
| RTECS | UR8432000 |
| Toxicity | LD50 i.p. in mice: 517 mmol/kg (Ruenitz, Mokler) |
Disopyramide - Reference Information
| biological activity | Disopyramide (Dicorantil) is a class IA anti-arrhythmic agent for both laboratory and atrial arrhythmias. Disopyramide blocked the rapid inward sodium current in the myocardium to prolong the duration of myocardial action potential. Disopyramide inhibits HERG-encoded potassium channels. Disopyramide also exhibits complex protein binding and a strong negative inotropic effect. |
| Use | cardiac medicine. Antiarrhythmic, suitable for supraventricular ventricular premature beat, all kinds of tachycardia atrial fibrillation. |
| production method | condensation and hydrolysis of 2-bromopyridine with benzonitrile and N,N-diisopropylchloroethylamine, and then with phosphoric acid to form salt that is to get the treatment of arrhythmia drug Dipyridamole. |
Last Update：2024-04-09 21:32:09
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Product Name: Disopyramide Visit Supplier Webpage Request for quotationCAS: 3737-09-5
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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