Dllsopropyl
Isoprothiolane
CAS: 50512-35-1
Molecular Formula: C12H18O4S2
Dllsopropyl - Names and Identifiers
Dllsopropyl - Physico-chemical Properties
| Molecular Formula | C12H18O4S2 |
| Molar Mass | 290.4 |
| Density | 1.3402 (rough estimate) |
| Melting Point | 54°C |
| Boling Point | 402.48°C (rough estimate) |
| Flash Point | 159°C |
| Water Solubility | 54 mg l-1 (25 °C) |
| Vapor Presure | 1.9 Pa (25 °C) |
| Appearance | neat |
| BRN | 2128528 |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Sensitive | Sensitive to light |
| Refractive Index | 1.4950 (estimate) |
| MDL | MFCD00210314 |
| Physical and Chemical Properties | Pure white crystals. m. P. 54~55 ℃, B. P. 167~169 ℃/66.66, relative density 1.044, vapor pressure 1.866 × 10-2Pa(25 ℃). Solubility in organic solvents at 25 ℃: acetone 400%, benzene 300%, toluene 230%, chloroform 230%, dimethylformamide 230%, dimethyl sulfoxide 190%, methanol 150%, ethanol 150%, n-hexane 4%; the solubility in water was 48mg/L (20 °c). Rice blast can be oxidation, reduction, hydrolysis reaction. Industrial products are yellow crystals with irritating odor. m. P. 50-51 °c. |
| Use | It is an organic sulfur fungicide with high efficiency, low toxicity and low residue, which is used to control Rice neck blast, rice leaf blast, rice seedling blast and so on |
Dllsopropyl - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HS Code | 29341000 |
| Toxicity | LD50 oral in rabbit: 2320mg/kg |
Dllsopropyl - Upstream Downstream Industry
| Raw Materials | Benzene Sulfuric acid Isopropanol |
Dllsopropyl - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Fungicide | Rice blast is also called Fuji One. The internal absorption of strong selective heterocyclic fungicides mainly prevents rice blast. In 1969, it was developed by the Japanese Pesticide Company as a fungicide. The original drug is white crystal with a slight sulfur odor. It has a solubility of 48 mg/L in water at 20 ℃, and is easily soluble in acetone, chloroform, xylene, benzene, methanol, ethanol and other solvents. Stable to light and temperature, stable at pH 3~10, but unstable under ultraviolet rays in water. A systemic fungicide promoted by the Japanese Pesticide Company in 1975. It has preventive and therapeutic effects on rice blast, and also treats leafhoppers and planthoppers. Young nymphs have incomplete molting or cannot molt and die after receiving the medicine. The main effect on Magnaporthe grisea is to inhibit phospholipid N-methyltransferase, thereby hindering the formation of fatty acids, triglycerides, and phospholipids. When the liquid medicine reaches 10 mg/kg, the formation of bacteria invasion thrombus is obviously inhibited, and the growth of mycelium is also inhibited. The disease spots on the plant cannot expand, and the absorption performance and durability of the agent on rice are good. It can be applied in the seedling raising box, and can also be sprayed in the field at the spike stage to prevent seedling blast and ear neck blast. It is safe to plants and low in toxicity to humans and animals. Rats (♀) Acute oral LD501340 mg/kg, percutaneous LD50>10250 mg/kg. There was no positive reaction in chronic toxicity test and no effect on bees, birds and natural enemies. Carp TLm(48 h) was 6.7 mg/kg, the safety interval of the last medication was 21 days, and the maximum allowable residue in brown rice was 2 mg/kg (Japan). |
| application | rice blast is mainly used to control rice blast. It is effective against both panicle blast and leaf blast, but it is better against panicle blast. Its quick effect is not as good as that of Kefen Powder and Isobanea, but its effect is better than that of both, and it can still maintain sufficient control effect 56 days after application. It is usually applied by spraying method, and the dosage is 360~450g/ha of active ingredient. No phytotoxicity to crops at effective doses. The safety interval is 14 days. |
| toxicity | acute oral LD50 of male rats is 1190 mg/kg, that of male mice is 1340 mg/kg, and that of rats is> 10250 mg/kg. No irritation to rabbit skin and eyes. The 2-year feeding test had no effect on 1.6 mg/kg per day for male rats and 3.1 mg/kg per day for dogs. Animal experiments showed no carcinogenic, teratogenic and mutagenic effects. Carp LC50 was 6.7mg/L (48h), rainbow trout LC50 was 6.8mg/L (48h), Daphnia LC50>100mg/L (48h). There is no effect on birds, poultry and bees within the usual dose. After ingesting the organism, it can be decomposed and removed without accumulation. |
| use | systemic fungicide. It has a special effect on rice blast. After the rice plant is absorbed, it can inhibit the invasion of bacteria, especially the phosphorus ester N-methyltransferase, thereby inhibiting the growth of bacteria, and playing a preventive and therapeutic role. This medicine also has the effect of inhibiting the density of rice planthopper and white-backed planthopper. To prevent and control leaf blast and ear blast, spray 7.5kg of water with 40% emulsifiable concentrate or 40% wettable powder 11.3~15g/100 m2 at the beginning of acute disease spot. The prevention and control of rice blast is applied once in the break period and the full spike period. It can also be used to prevent corn large and small leaf spot, barley stripe and moire. It is a high-efficiency, low-toxicity, and low-residue organic sulfur fungicide, which is used to prevent and control rice neck blast, rice leaf blast, rice seedling blast, etc. It is a systemic fungicide, which is used to prevent and control rice neck blast., Rice leaf blast and globule sclerotia, etc. This product is a systemic fungicide, which has special effects on rice neck blast, and its control effect on rice leaf blast is also higher than that of rice blast, it is also effective for rice seedling blast and globule sclerotiorum. Large-scale use can also treat rice planthoppers. |
| production method | made with diisopropyl malonate and carbon disulfide as the main raw materials. The production method of diisopropyl malonate: sodium chloroacetate reacts with sodium cyanide and sodium hydroxide to form sodium malonate. In the presence of sulfuric acid, sodium malonate reacts with isopropanol to form diisopropyl malonate. Raw material consumption quota: 760 kg/t of chloroacetic acid (folded 100%), 410 kg/t of sodium cyanide (folded 100%), 220 kg/t of dissimilatory alcohol (folded 100%), 710 kg/t of carbon disulfide (folded 100%), 810 kg/t of dichloroethane (folded 100%). in sodium hydroxide aqueous solution (8g sodium hydroxide dissolved in 50mL of water), 7.6g (0.1 mol) carbon disulfide and 18.8g (0.1 mol) diisopropyl malonate mixed solution were stirred and dropped at 10~20 ℃. After dropping, stirring at room temperature for 1h, 120mL of water and 50g (0.5mol) of 1, 2-dichloroethane were added and heated to 40~60 ℃. At the end of the reaction, extract with ether, wash, dry, and evaporate to remove excess 1,2-dichloroethane and ether to obtain 24.5g of yellow and white crystalline rice blast with 84.5% yield. Recrystallized with n-hexane to obtain a pure product with m.p. being 51~52 ℃. |
| category | pesticide |
| toxicity classification | low toxicity |
| acute toxicity | oral-rat LD50: 1190 mg/kg; Oral-mouse LD50: 1340 mg/kg |
| flammability hazard characteristics | combustion produces toxic sulfur oxide gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | dry powder, foam, sand |
Last Update：2024-04-10 22:29:15
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CAS: 50512-35-1
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Raw Materials for Dllsopropyl