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Dorzolamide

Dorzolamide

CAS: 120279-96-1;139066-77-6;149249-72-9

Molecular Formula: C10H16N2O4S3

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Dorzolamide - Names and Identifiers

Name Dorzolamide
Synonyms Dorzolamide
DORZOLAMIDE
4S,6S-Dorzolamide
Dorzalamide hydrochloride
DORZOLAMIDE(SUBJECTTOPATENTFREE)
(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-7,
4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
(2r,4r)-2-ethylamino-4-methyl-5,5-dioxo-5,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
(4R,6R)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
(4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S-cis)-
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4R-cis)-
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S-trans)-
CAS 120279-96-1
139066-77-6
149249-72-9
EINECS 1533716-785-6
InChI InChI=1/C10H18N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-8,10,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,7?,8-,10?/m0/s1

Dorzolamide - Physico-chemical Properties

Molecular FormulaC10H16N2O4S3
Molar Mass324.44
Density1.53±0.1 g/cm3(Predicted)
Boling Point575.8±60.0 °C(Predicted)
Solubility DMSO: soluble5mg/mL (clear solution, warmed)
Appearancepowder
Colorwhite to beige
pKapKa 6.35 (Uncertain);8.50 (Uncertain)
Storage Conditionroom temp
Refractive Index1.626
Physical and Chemical Properties

In vitro study Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC 50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM).
In vivo study Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively). Animal Model: Female Swiss albino mice (EAC solid tumor). Dosage: 3, 10, or 30 mg/kg/day (synergized mitomycin C). Administration: IP, daily for 3 weeks. Result: Upregulated TXNIP and p53 while downregulated bcl-2. Effective in retarding the growth of EAC in mice.

Dorzolamide - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany3
RTECSXJ9095169

Dorzolamide - Preparation Method

Open Data Verified Data

4-hydroxy 5,6-= hydro-6-tetra-4h-thieno [2,3-b] thiane-7, 7-= oxide mixed with acetonitrile, the reaction is carried out by slowly adding concentrated sulfuric acid, and the obtained product is sulfonated with chlorosulfonic acid or sulfuric acid, and then reacted with thionyl chloride to convert to sulfonyl chloride. The material in Tetrahydrofuran, the addition of ammonia, reaction to obtain sulfonamide, after reduction, that is to obtain the product, hydrochloric acid to obtain its hydrochloride.

Last Update：2024-01-02 23:10:35

Dorzolamide - Use

Open Data Verified Data

developed by Merck Co, Inc., USA, was first launched in the United States in 1995. Carbonic anhydrase inhibitors. For the treatment of glaucoma.

Last Update：2022-01-01 09:24:29
Dorzolamide
Supplier List
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
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CAS: 120279-96-1
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Multiple Specifications
Product Name: Dorzolamide Visit Supplier Webpage Request for quotation
CAS: 120279-96-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Product Name: Dorzolamide Monomer Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Dorzolamide Request for quotation
CAS: 120279-96-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple Specifications
Product Name: Dorzolamide Visit Supplier Webpage Request for quotation
CAS: 120279-96-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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Dorzolamide
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