E6446
6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole
CAS: 1219925-73-1
Molecular Formula: C27H35N3O3
E6446 - Names and Identifiers
E6446 - Physico-chemical Properties
| Molecular Formula | C27H35N3O3 |
| Molar Mass | 449.59 |
| Density | 1.151±0.06 g/cm3(Predicted) |
| Boling Point | 587.7±50.0 °C(Predicted) |
| pKa | 10.16±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Use | E6446 is a TLR inhibitor. E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA, which stimulates TLR9. |
| Target | TLR7； TLR9；TLR 7 and 9 |
E6446 - Reference
| Reference Show more | 1: Ishikawa T, Abe K, Takana-Ishikawa M, Yoshida K, Watanabe T, Imakiire S, Hosokawa K, Hirano M, Hirano K, Tsutsui H. Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats. J Am Heart Assoc. 2021 Apr 6;10(7):e019247. doi: 10.1161/JAHA.120.019247. Epub 2021 Mar 31. PMID: 33787285; PMCID: PMC8174358. 2: Mohammadi O, Krieger D, Butt I, Danckers M. A Case of Delayed Diagnosis of Moyamoya Disease After Recurrent Strokes. Cureus. 2019 Dec 22;11(12):e6446. doi: 10.7759/cureus.6446. PMID: 32010532; PMCID: PMC6975246. 3: Ueda H, Yamaguchi O, Taneike M, Akazawa Y, Wada-Kobayashi H, Sugihara R, Yorifuji H, Nakayama H, Omiya S, Murakawa T, Sakata Y, Otsu K. Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice. JACC Basic Transl Sci. 2019 May 22;4(3):348-363. doi: 10.1016/j.jacbts.2019.01.002. PMID: 31312759; PMCID: PMC6610159. 4: Monteiro WP, Veiga JC, Silva AR, Carvalho CDS, Lanes ÉCM, Rico Y, Jaffé R. Everything you always wanted to know about gene flow in tropical landscapes (but were afraid to ask). PeerJ. 2019 Feb 13;7:e6446. doi: 10.7717/peerj.6446. PMID: 30783576; PMCID: PMC6377592. 5: Yoshida K, Abe K, Ishikawa M, Saku K, Shinoda-Sakamoto M, Ishikawa T, Watanabe T, Oka M, Sunagawa K, Tsutsui H. Inhibition of TLR9-NF-κB-mediated sterile inflammation improves pressure overload-induced right ventricular dysfunction in rats. Cardiovasc Res. 2019 Mar 1;115(3):658-668. doi: 10.1093/cvr/cvy209. PMID: 30239623. |
E6446 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.224 ml | 11.121 ml | 22.242 ml |
| 5 mM | 0.445 ml | 2.224 ml | 4.448 ml |
| 10 mM | 0.222 ml | 1.112 ml | 2.224 ml |
| 5 mM | 0.044 ml | 0.222 ml | 0.445 ml |
Last Update：2024-01-02 23:10:35
E6446 - Reference Information
| biological activity | E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signal transduction in a variety of human and mouse cell types, and inhibits DNA-TLR9 interactions in vitro. |
| target | TargetValue TLR7 () TLR9 () DNA-TLR9 () |
| Target | Value |
Last Update：2024-04-09 20:49:11
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Tel: 609-228-6898
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Mobile: 609-228-6898
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Product Name: E-6446 Visit Supplier Webpage Request for quotationCAS: 1219925-73-1
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Mobile: +86-18621343501
QQ: 2881950922
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Tel: +86-18821248368
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Product Name: 6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole Visit Supplier Webpage Request for quotationCAS: 1219925-73-1
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