E7386

Name	PVM/MA
Synonyms	E7386 E-7386 s-22611 PF06291874 Vorasidenib FM381 FM-381 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine
CAS	1644545-52-7

Molecular Formula	C14H13ClF6N6
Molar Mass	414.74
Density	1.491±0.06 g/cm3(Predicted)
Boling Point	467.5±55.0 °C(Predicted)
pKa	1.49±0.41(Predicted)
Storage Condition	2-8℃
In vitro study	A pan-IDH1/2 inhibitor (AG881) selectively inhibits mutant IDH proteins and induces cell differentiation in in vitro and in vivo models. AG-881 inhibits the conversion of α-kg to cancer metabolite 2HG, inhibits 2HG-mediated signaling, and causes cell differentiation. Proliferation of tumor cells expressing mutant IDH is inhibited.
In vivo study	AG-881 can completely cross the blood-brain barrier. At present, AG-881 is in the early clinical Phase I trial to detect its effect on the treatment of malignant hematological diseases, solid tumors and gliomas with IDH mutations.

biological activity	Vorasidenib (AG-881) is an orally active inhibitor targeting mutant IDH1 and idh2.
Target	Value

Last Update：2024-04-09 20:49:11

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CAS: 1644545-52-7
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Product Name: PVM/MA Visit Supplier Webpage Request for quotation
CAS: 1644545-52-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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E7386

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