EAMTD

Name	2-Acetamido-5-mercapto-1,3,4-Thiadiazole
Synonyms	AMT EAMTD 2-Acetamido-5-mercapto-1,3,4-Thiadiazole 2-Acetylamino-5-mercapto-1,3,4-thiadiazole 2-ACETYLAMINO-5-MERCAPTO-1,3,4-THIADIAZOLE ACETYLAMINE(2-)-5-MERCAPTO-1,3,4-THIADAZOLE 2-ACETYLAMINO-5-MERCAPTO-1,3,4-THIADIAZOLE (AMTD) N-(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)acetamide N-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)acetamide N-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide
CAS	32873-56-6
EINECS	251-275-0
InChI	InChI=1/C4H5N3OS2/c1-2(8)5-3-6-7-4(9)10-3/h1H3,(H,7,9)(H,5,6,8)

Molecular Formula	C4H5N3OS2
Molar Mass	175.23
Density	1.71±0.1 g/cm3(Predicted)
Melting Point	208-210 °C (decomp)(Solv: ethanol (64-17-5))
Solubility	DMSO (Slightly), Methanol (Slightly, Heated)
Appearance	Solid
Color	White to Pale Yellow
pKa	5.31±0.40(Predicted)
Storage Condition	Refrigerator
Refractive Index	1.794
Use	Used as a pharmaceutical Intermediate

Use	Used as a pharmaceutical intermediate The intermediate of the drug acetazolamide.
Production method	It is obtained by acetylation of 2-amino-5-mercapto-1, 3,4-thiadiazole. The target product can be obtained by heating 2-amino -5-mercapto -1,3, 4-thiadiazole, glacial acetic acid and acetic anhydride together and refluxing for 1.5h.

Last Update：2024-04-10 22:29:15

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