ELECTROCORTIN
Aldosterone
CAS: 52-39-1
Molecular Formula: C21H28O5
ELECTROCORTIN - Names and Identifiers
| Name | Aldosterone |
| Synonyms | Aldosterone REICHSTEIN X LECTROCORTIN ELECTROCORTIN 18-Oxocorticosterone 11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al 11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al 21-dihydroxy-3,20-dioxo-1(11beta)-pregn-4-en-18-a 21-dihydroxy-3,20-dioxo-1(11-beta)-pregn-4-en-18-a |
| CAS | 52-39-1 |
| EINECS | 200-139-9 |
| InChI | InChI=1/C21H28O5/c1-20-7-6-12(23)8-11(20)2-3-13-14-4-5-15(16(24)10-22)21(14)9-17(18(13)20)26-19(21)25/h8,13-15,17-19,22,25H,2-7,9-10H2,1H3 |
ELECTROCORTIN - Physico-chemical Properties
| Molecular Formula | C21H28O5 |
| Molar Mass | 360.45 |
| Density | 1.28 |
| Melting Point | 170-172°C |
| Boling Point | 412.46°C (rough estimate) |
| Specific Rotation(α) | D23 +152.2° (anhydr; c = 2 in acetone); D25 +161° (c = 0.1 in chloroform) |
| Flash Point | 2℃ |
| Water Solubility | 51.18mg/L(37 ºC) |
| Solubility | Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 6.23E-16mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | White |
| Merck | 13,224 |
| BRN | 3224996 |
| pKa | 12.98±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.6120 (estimate) |
| MDL | MFCD00051136 |
| In vitro study | Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner. |
ELECTROCORTIN - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN 1648 3 / PGII |
| WGK Germany | 3 |
| RTECS | TU4523000 |
| FLUKA BRAND F CODES | 22-24-25 |
| HS Code | 29372900 |
ELECTROCORTIN - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | Aldosterone are primary mineralocorticoids. Aldosterone is a steroid hormone that is synthesized and secreted by the glomerular region (ZG) of the adrenal cortex in response to activation of the renin-angiotensin system (RAS) or high potassium diet. Aldosterone activity depends on the binding and activation of cytoplasmic/nuclear mineralocorticoid receptor (MR) at the cellular level. |
| Animal Model: | Forty male Wistar rats |
| Dosage: | 1 mg/Kg (+1% NaCl) |
| Administration: | i.h.; once daily for 3 weeks |
| Result: | Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals. |
| category | toxic substances |
| flammability hazard characteristics | flammability; combustion emissions stimulate smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food additives |
| fire extinguishing agent | foam, sand, carbon dioxide, dry powder, mist water |
Last Update：2024-04-09 15:16:50
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