Name | EMD638683 |
Synonyms | EMD638683 ]-2-ethyL EMD-638683 EMD 638683 N'-[2-(3,5-DifL )-2-hydroxyacetyL N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide 3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide |
CAS | 1181770-72-8 |
Molecular Formula | C18H18F2N2O4 |
Molar Mass | 364.34 |
Density | 1.363±0.06 g/cm3(Predicted) |
Boling Point | 657.6±55.0 °C(Predicted) |
pKa | 8.68±0.25(Predicted) |
Storage Condition | -20℃ |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.745 ml | 13.723 ml | 27.447 ml |
5 mM | 0.549 ml | 2.745 ml | 5.489 ml |
10 mM | 0.274 ml | 1.372 ml | 2.745 ml |
5 mM | 0.055 ml | 0.274 ml | 0.549 ml |
biological activity | emd63883 is a highly selective inhibitor of serum- and glucocorticoid-inducible kinase 1 (SGK1), the IC50 value was 3 μm. Emd6386 83 has antihypertensive efficacy and antitumor activity. |
Target | TargetValue SGK1 (Cell-free assay) 3 μm |
Target | Value |
SGK1 (Cell-free assay) | 3 μM |