ENT-3 - Names and Identifiers
Name | (1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane
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Synonyms | ENT-3 Entecavir intermediate 3 Entecavir intermediate N3 1R,2R-2-[(Phenylmethoxy)methyl]-3-cyclopenten-1-ol (1S,2R,3S,5R)-3-(Benzyloxymethyl)-6-oxabicyclo[3.1.0]hexane (1S,2R,3S,5R)-3-(benzyloxy)-2-[(benzyloxy)methyl]-6-oxabicyclo[3.1.0]hexane (1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane (1S,2R,3S,5R)-3-(benzyloxy)-2-((4-methylbenzyloxy)methyl)-6-oxabicyclo[3.1.0]hexane (1S,2R,3S,5R)-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane [1S-(1a,2a,3,5a)]-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane [1S-(1α,2α,3β,5α)]-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane 6-Oxabicyclo[3.1.0]hexane, 3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-, (1S, 2R, 3S, 5R)
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CAS | 110567-22-1
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EINECS | 1592732-453-0 |
InChI | InChI=1/C20H22O3/c1-3-7-15(8-4-1)12-21-14-17-18(11-19-20(17)23-19)22-13-16-9-5-2-6-10-16/h1-10,17-20H,11-14H2/t17-,18+,19-,20+/m1/s1 |
ENT-3 - Physico-chemical Properties
Molecular Formula | C20H22O3
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Molar Mass | 310.39 |
Density | 1.17 |
Boling Point | 427.9±40.0 °C(Predicted) |
Flash Point | 145.852°C |
Solubility | Benzene, Chloroform, DMSO, Methanol |
Vapor Presure | 0mmHg at 25°C |
Appearance | Oil |
Color | Colorless to Pale Yellow |
Storage Condition | Sealed in dry,2-8°C |
Refractive Index | 1.593 |
ENT-3 - Risk and Safety
Safety Description | 24/25 - Avoid contact with skin and eyes.
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HS Code | 29329990 |
ENT-3 - Introduction
(1S,2R,3S,5R)-3-(benzyloxy)-2-[(benzyloxy) methyl]-6-oxabicyclo [3.1.0] hexane is an organic compound also known as 1,2, 3,5-tetraoxabicyclo [3.1.0] hexane.
Nature:
-Appearance: colorless liquid
-Molecular formula: C14H18O3
-Molecular weight: 234.29g/mol
Use:
(1S,2R,3S,5R)-3-(benzyloxy)-2-[(benzyloxy) methyl]-6-oxabicyclo [3.1.0] hexane has important application value in the field of drugs, and is often used as a synthetic intermediate of hypnotics, anxiolytics and antiepileptic drugs.
Preparation Method:
The preparation method of
(1S,2R,3S,5R)-3-(benzyloxy)-2-[(benzyloxy) methyl]-6-oxabicyclo [3.1.0] hexane is complicated, and a common synthetic route is to obtain the target product through a ring-closing reaction. The specific synthetic steps vary depending on factors such as reaction conditions and configuration.
Safety Information:
At present, the safety and toxicity of the compound are limited, so we should pay attention to the correct operation and laboratory safety. Wear personal protective equipment such as goggles, gloves, and protective clothing when using or handling the compound. At the same time, pay attention to avoid inhalation, intake and contact with skin. Dispose of waste and solvents generated during operation and comply with local codes and regulations. To ensure safety, please refer to the relevant safety data sheet (MSDS) of the chemical.
Last Update:2024-04-09 21:11:58