EOS-60954
1H-Benzimidazole, 1-[(4-methylphenyl)sulfonyl]-
CAS: 15728-44-6
Molecular Formula: C14H12N2O2S
EOS-60954 - Names and Identifiers
EOS-60954 - Physico-chemical Properties
| Molecular Formula | C14H12N2O2S |
| Molar Mass | 272.32 |
EOS-60954 - Introduction
1H-Benzimidazole, 1-[(4-methylphenyl)sulfonyl]-is an organic compound commonly abbreviated as Tos-BnIm. It has the following properties:
Nature:
-Appearance is white solid
-Soluble in organic solvents such as chloroform, dichloromethane and benzene
-Stable in the air, but avoid prolonged exposure to the Sun
-Has strong electron acceptor properties and can be used as an electrophilic additive reagent
Use:
- 1H-Benzimidazole, 1-[(4-methylphenyl)sulfonyl]-commonly used in catenary reactions and cyclic reactions in organic synthesis
-Can be used in the field of organic synthesis such as catalytic acylation reaction, cyclization reaction and carbon-nitrogen coupling reaction
-In drug synthesis, it can be used to prepare Arylamine compounds and charged nitrogen heterocyclic compounds
Method:
- 1H-Benzimidazole, 1-[(4-methylphenyl)sulfonyl]-can be prepared by esterification of benzyl benzoate and p-Toluenesulfonyl fluoride to obtain 1H-Benzimidazole, 1-[(4-methylphenyl)) sulfonyl]-. The reaction conditions are generally Basic under inert atmosphere.
Safety Information:
- 1H-Benzimidazole, 1-[(4-methylphenyl)sulfonyl]-is relatively safe under regular operation, but protective measures still need to be paid attention.
-Wear appropriate personal protective equipment such as protective gloves, goggles and protective clothing for use.
-Avoid skin contact and inhalation, avoid ingestion.
-In case of contact with skin or eyes, rinse immediately with plenty of water for at least 15 minutes and seek medical attention.
-Operate in a well-ventilated place, and keep away from combustibles such as fire and organic solvents.
Nature:
-Appearance is white solid
-Soluble in organic solvents such as chloroform, dichloromethane and benzene
-Stable in the air, but avoid prolonged exposure to the Sun
-Has strong electron acceptor properties and can be used as an electrophilic additive reagent
Use:
- 1H-Benzimidazole, 1-[(4-methylphenyl)sulfonyl]-commonly used in catenary reactions and cyclic reactions in organic synthesis
-Can be used in the field of organic synthesis such as catalytic acylation reaction, cyclization reaction and carbon-nitrogen coupling reaction
-In drug synthesis, it can be used to prepare Arylamine compounds and charged nitrogen heterocyclic compounds
Method:
- 1H-Benzimidazole, 1-[(4-methylphenyl)sulfonyl]-can be prepared by esterification of benzyl benzoate and p-Toluenesulfonyl fluoride to obtain 1H-Benzimidazole, 1-[(4-methylphenyl)) sulfonyl]-. The reaction conditions are generally Basic under inert atmosphere.
Safety Information:
- 1H-Benzimidazole, 1-[(4-methylphenyl)sulfonyl]-is relatively safe under regular operation, but protective measures still need to be paid attention.
-Wear appropriate personal protective equipment such as protective gloves, goggles and protective clothing for use.
-Avoid skin contact and inhalation, avoid ingestion.
-In case of contact with skin or eyes, rinse immediately with plenty of water for at least 15 minutes and seek medical attention.
-Operate in a well-ventilated place, and keep away from combustibles such as fire and organic solvents.
Last Update：2024-04-09 02:00:42
