Name | ERDAFITINIB |
Synonyms | Erdafitinib ERDAFITINIB JNJ-42756493 Suftalan Zine Erdafitinib(JNJ-42756493) N-(3,5-dimethoxyphenyl)-N'-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine N1-(3,5-Dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine |
CAS | 1346242-81-6 |
Molecular Formula | C25H30N6O2 |
Molar Mass | 446.5447 |
Density | 1.20±0.1 g/cm3(Predicted) |
Melting Point | 136-140°C |
Boling Point | 662.3±55.0 °C(Predicted) |
Solubility | DMSO: ≥ 33 mg/mL |
Appearance | Form Solid, Color Yellow |
pKa | 9.45±0.29(Predicted) |
Storage Condition | -20°C Freezer, Under inert atmosphere |
Physical and Chemical Properties | Bioactive Erdafitinib (JNJ-42756493) is an effective, selective and oral biologically active panfibroblast growth factor receptor FGFR inhibitor with potential anti-tumor activity. Erdafitinib can also combine RET (c-RET), CSF-1R, PDGFR-α/PDGFR-β, FLT4, Kit (c-Kit) and VEGFR-2 and induce apoptosis. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.239 ml | 11.197 ml | 22.394 ml |
5 mM | 0.448 ml | 2.239 ml | 4.479 ml |
10 mM | 0.224 ml | 1.12 ml | 2.239 ml |
5 mM | 0.045 ml | 0.224 ml | 0.448 ml |