Molecular Formula | C17H11BrFN3O2 |
Molar Mass | 388.19 |
Density | 1.628±0.06 g/cm3(Predicted) |
Boling Point | 525.1±50.0 °C(Predicted) |
Solubility | DMSO |
pKa | 12.92±0.50(Predicted) |
Storage Condition | 2-8°C |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.576 ml | 12.88 ml | 25.761 ml |
5 mM | 0.515 ml | 2.576 ml | 5.152 ml |
10 mM | 0.258 ml | 1.288 ml | 2.576 ml |
5 mM | 0.052 ml | 0.258 ml | 0.515 ml |
biological activity | ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor, the IC50 values for ERK5 and ERK5 MEF2D were 0.82 μm and 3 μm, respectively. |
Target | Value |
ERK5 (Cell-free assay) | 0.82 μM |
ERK5 MEF2D (Cell-free assay) | 3 μM |