EXP3174
2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID
CAS: 124750-92-1
Molecular Formula: C22H21ClN6O2
EXP3174 - Names and Identifiers
| Name | 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID |
| Synonyms | E3174 E-3174 E 3174 EXP3174 EXP-3174 EXP 3174 AKOS 91941 E-3174, EXP-3174 LOSARTAN CARBOXY ACID '-biphenyl)-4-yl)methyl)- 1h-imidazole-5-carboxylicacid,2-butyl-4-chloro-1-((2'-(14-tetrazol-5-yl)(1,1 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID |
| CAS | 124750-92-1 |
| EINECS | 1592732-453-0 |
EXP3174 - Physico-chemical Properties
| Molecular Formula | C22H21ClN6O2 |
| Molar Mass | 436.89 |
| Density | 1.41±0.1 g/cm3(Predicted) |
| Melting Point | 130-132°C |
| Boling Point | 707.8±70.0 °C(Predicted) |
| Solubility | Dimethylformamide, Dimethyl Sulfoxide, Methanol |
| Appearance | Solid |
| Color | Light-Yellow |
| pKa | 0.79±0.50(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| In vitro study | The specific binding of [125I]-angiotensin II to VSMC is inhibited by Losartan Carboxylic Acid (E-3174) with an IC 50 of 1.1 nM. Losartan Carboxylic Acid abolishes the angiotensin II-induced formation of inositolphosphates in VSMC. Losartan Carboxylic Acid inhibits the angiotensin II-induced elevation of intracellular cytosolic Ca2+ concentration with an IC 50 of 5 nM. Losartan Carboxylic Acid is more effective than losartan in blocking the angiotensin II-induced increase in Egr-1 mRNA. Losartan Carboxylic Acid inhibits the angiotensin II-induced cell protein synthesis with an IC 50 of 3 nM. |
EXP3174 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29339900 |
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Product Name: 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID Visit Supplier Webpage Request for quotationCAS: 124750-92-1
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Mobile: 18021002903
QQ: 3008007409
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Spot supply
Product Name: Losartan Impurity 14 Visit Supplier Webpage Request for quotationCAS: 124750-92-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID Visit Supplier Webpage Request for quotationCAS: 124750-92-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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