Enrofloxacine
Enrofloxacin
CAS: 93106-60-6
Molecular Formula: C19H22FN3O3
Enrofloxacine - Names and Identifiers
| Name | Enrofloxacin |
| Synonyms | Enrofloxacin Enrofloxacine ROFLOXACIN BASE enrofloxacin Baytril EnrofloxacinBaseCpv2000 Enorofloxacin hydrochloride ENROFLOXACIN MM(CRM STANDARD) 1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinoli 1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
| CAS | 93106-60-6 |
| EINECS | 618-911-2 |
| InChI | InChI=1/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26) |
Enrofloxacine - Physico-chemical Properties
| Molecular Formula | C19H22FN3O3 |
| Molar Mass | 359.39 |
| Density | 1.385±0.06 g/cm3(Predicted) |
| Melting Point | 225 °C |
| Boling Point | 560.5±50.0 °C(Predicted) |
| Water Solubility | Soluble in chloroform. Slightly soluble in water. Also soluble in dilute KOH |
| Solubility | DMSO:8 mg/ml requires ultrasonic mother liquor storage: sub-package and freeze storage to avoid repeated freezing and thawing;-20 ℃,1 month;-80 ℃,6 months (after dilution, the solution temperature is low and storage may precipitate, and it may be used as soon as possible) Cell experiment: dissolve with DMSO first: dilute with culture medium and dilute |
| Appearance | powder or crystals |
| Color | Pale Yellow to Light Beige |
| Merck | 14,3592 |
| BRN | 5307824 |
| pKa | 6.43±0.41(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| MDL | MFCD00792463 |
| Physical and Chemical Properties | This product belongs to the third generation quinolone antibacterial drug, is a special veterinary drug, is a kind of white or yellowish crystalline needle powder, melting point 221-226 ℃, odorless, tasteless. Commonly used its hydrochloride, lactate, sodium salt. The product is dissolved under acidic or alkaline conditions, slightly soluble in dimethylformamide and chloroform, slightly soluble in methanol, and insoluble in water. The color of this product is deepened by long-term light. It is stored in places with high relative humidity and is easy to absorb moisture and agglomerate. |
Enrofloxacine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | VB1993650 |
| HS Code | 29339900 |
| Toxicity | LD50 in male, female mice (mg/kg): >5000, 4336 orally; ~200, ~200 i.v.; in male rats, male rabbits (mg/kg): >5000, 500-800 orally (Altreuther) |
Enrofloxacine - Reference
| Reference Show more | 1. Wang Yanling, Liu Junyan, Sun Jia Ni, etc. Theoretical study on the molecular imprinting of enrofloxacin and methacrylic acid [J]. Chinese Journal of Polymer Science, 2013(12):001525-1530. 2. Liu Junyu, Tang Shanshan, Sun jiaini, etc. Theoretical study on self-assembly system of molecularly imprinted polymers based on ciprofloxacin and trifluoromethacrylic acid [J]. Chemical Journal of Chinese universities, 2013, 34(011):002566-2573. 3. Liu Minfang, Cao mengrui, Li Rongxu, etc. Isolation, identification and drug sensitivity analysis of salmonella from waterfowl in some areas of Guangdong province [J]. Heilongjiang Journal of Animal Science and Veterinary Medicine, 2018(10). 4. Tang Wanjin, Zhao Tong, Zhou Chunhong, etc. Synthesis of ofloxacin molecularly imprinted materials by complex functional monomer [J]. Journal of Lanzhou University (self-Science Edition), 2014, 000(001):136-144. 5. Ma Jun, Kongde, Han Xiaohong, et al. Surface-enhanced Raman spectroscopic study on detection of antibiotics in water using silver Sol film [J]. Spectroscopy and Spectral Analysis, 2013(10):2688-2693. 6. Liu Junyu, Wang Yanling, Tang Shanshan, etc. Preparation and characterization of enrofloxacin molecularly imprinted polymers [J]. Chinese Journal of Veterinary Medicine, 2014, 48(3):30-34. 7. Yu Lu, Liu Weihua, Liu Minxuan, etc. Rapid detection of ciprofloxacin residues in milk by colloidal gold immunochromatography [J]. Food Research and Development, 2019, v.40;No.371(22):167-171. 8. Zhao Suhua, fan Hongjie. Serotype identification and drug resistance analysis of avian Escherichia coli in northern Anhui [J]. Journal of Animal Husbandry and Veterinary Medicine, 2017, 49(004):95-98. 9. Wei Qinglan, Zhang Jipei, Ren Tao, et al. Drug Sensitivity Analysis of Escherichia coli from waterfowl in Guangdong province [J]. Heilongjiang Journal of Animal Husbandry and Veterinary Medicine, 2015, 000(012):180-181. 10. Xiao Youyu, Lu Fei, Zhang Chi, Wang Chen, Chen Zhu, Li Dongyuan, Tang Wei. Establishment of a new immunochromatographic assay for quantitative detection of enrofloxacin quantum dots [J]. Modern food science and technology, 2020,36(12):252-258. 11. Mei Hanjie, Chen Xihong, Hu Wenfeng, Xiao Diao, Li Guangyue. Screening and identification of a strain degrading enrofloxacin and optimization of its degradation conditions [J]. Science and Technology of food industry, 2021,42(05):105-112. 12. Chen Yunmeng, Liu Xing, Li Hongfei, Qin Huizhao, Li Ying, Yang Baolin. Study on the effect of Yiqi Fuyang formula on reducing uric acid in hyperuricemia rats [J]. Chinese Journal of Emergency Medicine, 2021,30(01):44-47. 13. Chen Shu-Xin, Wang Jing, He Shi-Chong, Liu Yan-Zheng, Feng Huajun, Mu Peng-Qian. Determination of 17 antibiotics in water by ultra performance liquid chromatography-tandem mass spectrometry [J]. China Environmental Monitoring, 2020,36(06):119-126. 14. Ahmed, Salah Uddin, et al. "Comparative Study on pharmacochemicals of Four Long-Acting Injectable Formulations of Enrofloxacin in Pigs." Frontiers in Veterinary Science 7 (2021): 1241.https://doi.org/10.3389/fvets.2020.604628 15. [IF=2.596] Jing Wang et al."The development of a biomimetic enzyme-linked immunosorbent assay based on the molecular imprinting technique for the detection of enrofloxacin in animal-based food."Anal Methods-Uk. 2017 Dec;9(47):6682-6688 16. [IF=1.81] Dai Zhengqiang et al."Optimization of enrofloxacin-imprinted polymers by computer-aided design."J Mol Model. 2015 Nov;21(11):1-9 17. [IF=7.514] Yanan Cao et al."Rapid and selective extraction of norfloxacin from milk using magnetic molecular imprinting polymers nanoparticles."Food Chem. 2021 Aug;353:129464 18. [IF=6.419] Yucai Wei et al."Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release."Drug Deliv. 2021;28(1):372-379 19. [IF=6.057] Song Hu et al."Reliable performance of aggregation-induced emission nanoparticle-based lateral flow assay for norfloxacin detection in nine types of animal-derived food."Talanta. 2020 Nov;219:121245 20. [IF=4.821] Huinan Sun et al."Development of a liquid crystal-based α-glucosidase assay to detect anti-diabetic drugs."Microchem J. 2021 Aug;167:106323 21. [IF=4.616] Huiwen Wang et al."Rapid quality control of medicine and food dual purpose plant polysaccharides by matrix assisted laser desorption/ionization mass spectrometry."Analyst. 2020 Mar;145(6):2168-2175 22. [IF=2.863] Yu Zhang et al."Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China."Food Sci Nutr. 2021 Nov;9(11):6152-6161 23. [IF=2.082] Qin Guo et al."Synergistic inhibition effects of tea polyphenols as adjuvant of oxytetracycline on Vibrio parahaemolyticus and enhancement of Vibriosis resistance of Exopalaemon carinicauda."Aquac Res. 2021 Aug;52(8):3900-3910 24. [IF=6.498] Jingyun Shi et al."Groundwater antibiotics and microplastics in a drinking-water source area, northern China: Occurrence, spatial distribution, risk assessment, and correlation."Environ Res. 2022 Jul;210:112855 25. [IF=4.223] Zhang Shiqiu et al."Enhanced removal of tetracycline via advanced oxidation of sodium persulfate and biochar adsorption."ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH. 2022 May;:1-12 26. [IF=6.498] Xiaofang Xue et al."Biocathode regulates enrofloxacin degradation by coupling with different co-metabolism conditions."Environ Res. 2022 Sep;212:113254 |
Enrofloxacine - Introduction
Odorless, tasteless. Commonly used its hydrochloride, lactate, sodium salt. The product is dissolved under acidic or alkaline conditions, slightly soluble in dimethylformamide and chloroform, slightly soluble in methanol, and insoluble in water. The color of this product is deepened by long-term light. Store in places with high relative humidity, easy to absorb moisture and agglomer.
Last Update：2022-10-16 17:30:14
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