Entospletinib
GS 9973
CAS: 1229208-44-9
Molecular Formula: C23H21N7O
Entospletinib - Names and Identifiers
Entospletinib - Physico-chemical Properties
| Molecular Formula | C23H21N7O |
| Molar Mass | 411.46 |
| Density | 1.45±0.1 g/cm3(Predicted) |
| pKa | 12.54±0.40(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | In vitro experiments, GS-9973 in Caco-2 cell monolayer membrane has a good two-way permeability. In cells, GS-9973 is also very selective for Syk, strongly inhibiting BCR-mediated B cell activation and proliferation, as well as immune complex-activated cytokine production in monocytes. The combined use of GS-9973 and idelalisib synergistically inhibited cell survival and disrupted chemokine signaling pathways. In vitro, GS-9973 had good bidirectional permeability in Caco-2 cell monolayer. In cells, GS-9973 is also very selective for Syk, strongly inhibiting BCR-mediated B cell activation and proliferation, as well as immune complex-activated cytokine production in monocytes. The combined use of GS-9973 and idelalisib synergistically inhibited cell survival and disrupted chemokine signaling pathways. |
| In vivo study | GS-9973 (1 mg/kg, oral) had moderate to high bioavailability in rats and dogs, respectively. In a rat collagen-induced arthritis model, GS-9973 (1-10 mg/kg, P. O.) significantly inhibited joint inflammation. In addition, GS-9973 also has disease-modifying activity, including inhibition of pannus formation, cartilage damage, bone erosion, tooth formation, etc., with ED50 from 1.2 to 3.9 mg/kg. GS-9973 (1 mg/kg, P. O.) had moderate to high bioavailability in rats and dogs, respectively. In a rat collagen-induced arthritis model, GS-9973 (1-10 mg/kg, P. O.) significantly inhibited joint inflammation. In addition, GS-9973 also has disease-modifying activity, including inhibition of pannus formation, cartilage damage, bone erosion, tooth formation, etc., with ED50 from 1.2 to 3.9 mg/kg. |
Entospletinib - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.43 ml | 12.152 ml | 24.304 ml |
| 5 mM | 0.486 ml | 2.43 ml | 4.861 ml |
| 10 mM | 0.243 ml | 1.215 ml | 2.43 ml |
| 5 mM | 0.049 ml | 0.243 ml | 0.486 ml |
Last Update：2024-01-02 23:10:35
Entospletinib - Introduction
GS 9973 is a chemical substance, which is commonly used in the dye industry. The following is a description of the properties, uses, preparation and safety information of the chemical substance:
Nature:
- GS 9973 is an organic compound with the chemical formula C10H8N2S.
-It is a white crystalline powder, soluble in organic solvents such as alcohols and ketones.
- GS 9973 is relatively stable to light and air.
Use:
- GS 9973 commonly used as organic dyes in the dye industry.
-It can be used for dyeing materials such as textiles, plastics, leather and paper.
- GS 9973 is commonly used in the preparation of pigments, dye printing inks and pigment powders.
Preparation Method:
- GS The preparation method of 9973 is usually achieved by chemical reaction.
-A common preparation method is to react thiophenol and thiourea under appropriate conditions to produce GS 9973.
Safety Information:
- GS 9973 may be irritating to the eyes, skin and respiratory system.
-Wear appropriate protective equipment such as gloves, glasses and masks when using.
-Avoid inhaling the dust of GS 9973, avoid contact with skin and eyes, if accidental contact, rinse with water immediately.
-In the use and storage process, should follow the chemical safety procedures, and do a good job of ventilation measures.
- GS 9973 should be stored in a dry, cool place, away from fire and oxidant.
Please note that the above information is for informational purposes only and that relevant safety standards and regulations should be followed when using and handling this chemical.
Nature:
- GS 9973 is an organic compound with the chemical formula C10H8N2S.
-It is a white crystalline powder, soluble in organic solvents such as alcohols and ketones.
- GS 9973 is relatively stable to light and air.
Use:
- GS 9973 commonly used as organic dyes in the dye industry.
-It can be used for dyeing materials such as textiles, plastics, leather and paper.
- GS 9973 is commonly used in the preparation of pigments, dye printing inks and pigment powders.
Preparation Method:
- GS The preparation method of 9973 is usually achieved by chemical reaction.
-A common preparation method is to react thiophenol and thiourea under appropriate conditions to produce GS 9973.
Safety Information:
- GS 9973 may be irritating to the eyes, skin and respiratory system.
-Wear appropriate protective equipment such as gloves, glasses and masks when using.
-Avoid inhaling the dust of GS 9973, avoid contact with skin and eyes, if accidental contact, rinse with water immediately.
-In the use and storage process, should follow the chemical safety procedures, and do a good job of ventilation measures.
- GS 9973 should be stored in a dry, cool place, away from fire and oxidant.
Please note that the above information is for informational purposes only and that relevant safety standards and regulations should be followed when using and handling this chemical.
Last Update：2024-04-10 22:29:15
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CAS: 1229208-44-9
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CAS: 1229208-44-9
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Product Name: GS 9973 Visit Supplier Webpage Request for quotation
CAS: 1229208-44-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1229208-44-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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