Equest
Moxidectin
CAS: 113507-06-5
Molecular Formula: C37 H53 N O8
Equest - Names and Identifiers
| Name | Moxidectin |
| Synonyms | Quest Equest proheart ProHeart 6 Moxidextin Moxidectin MilbemycinB Vetdectin Oral Drench 23-MethoxiMe-LL-F 28249α 5-O-demethyl-28-deoxy-25-(1E)-1,3-dimethyl-1-butenyl-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)- [6R,23E,25S(E)]-5-O-DeMethyl-28-deoxy-25-(1,3-diMethyl-1-butenyl)-6,28-epoxy-23-(MethoxyiMino)MilbeMycin B (6R,23E,25S)-5-O-DeMethyl-28-deoxy-25-[(1E)-1,3-diMethyl-1-buten-1-yl]-6,28-epoxy-23-(MethoxyiMino)MilbeMycin B (2aE,4E,4'E,5'S,6R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-4'-(methoxyimino)-5',6,8,19-tetramethyl-6'-[(2E)-4-methylpent-2-en-2-yl]-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-tetradecahydro-2H,17H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-17-one |
| CAS | 113507-06-5 |
| EINECS | 635-129-7 |
| InChI | InChI=1/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31-/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1 |
| InChIKey | YZBLFMPOMVTDJY-LSGXYNIPSA-N |
Equest - Physico-chemical Properties
| Molecular Formula | C37 H53 N O8 |
| Molar Mass | 639.82 |
| Density | 1.23±0.1 g/cm3(Predicted) |
| Melting Point | 132 °C |
| Boling Point | 790.0±70.0 °C(Predicted) |
| Appearance | neat |
| Color | White to Almost white |
| pKa | 12.46±0.70(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.581 |
| Physical and Chemical Properties | properties white or off-white amorphous powder |
| Use | Antiparasitic agents |
Equest - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R50 - Very Toxic to aquatic organisms |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | 2588 |
| WGK Germany | 3 |
| RTECS | PY5438800 |
| HS Code | 29322090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
Equest - Reference Information
| Use | Moxitin is a macrolide and semi-synthetic derivative of nimoctin. Moxitin is a parasiticide used to prevent and control filaria and intestinal worms. Moxidin is found in veterinary drugs used to treat animals such as dogs, cats, horses, cattle and sheep. |
| Overview | Moxidin is a semi-synthetic single-component macrolide antibiotic produced by Streptomyces fermentation, which is a derivative of nimoctin. Macrolide antiparasitic drugs are composed of two categories, namely abamectin and milbemycin. |
| application field | moxidin began to be used as a veterinary anthelmintic. As a new generation of deworming drugs, moxidin can effectively kill nematodes and body surface parasites, and has good safety for animals. It is superior to ivermectin in dosage, formulation development, drug resistance and drug distribution in vivo. |
| Side effects | Studies on moxidin have shown that side effects vary from animal to animal and may be affected by the formulation, application method and dosage of the product. An overdose of moxidin can enhance the effects of the following drugs: Gamma-aminobutyric acid (gabba) in the central nervous system. In horses, overdose may cause depression, lower lip ptosis, tremor, lack of coordination when moving (ataxia), reduced respiratory rate (respiratory rate), drowsiness and coma. If the dog licks moxitin from the skin, this is a "spot-smearing" (topical) therapy, which acts the same as an overdose and can cause vomiting, salivation, and neurological symptoms such as ataxia, tremor, and nystagmus. Some sheepdog dogs can tolerate moxitin, but others are sensitive and, once ingested, experience vomiting, salivation, or transient neurological symptoms. |
| pharmacological effects | moxidin is very lipophilic, resulting in a high circulation. moxidin is concentrated in the adipose tissue of animals and can be released for up to two months from the beginning of management. In goats, the oral bioavailability of moxidin is 2.7 times lower than that of sheep, and the half-life is 1.8 times shorter than that of sheep. |
| veterinary range | moxidin is approved for onchocerciasis according to two studies, 2018 in the United States people over 11 years old river blindness). Additional trials with long-term follow-up are necessary to assess whether moxidin is safe and effective in treating nematode infections in children and fertile women. Moxidin is expected to help achieve the goal of eliminating the disease. Dog: Prevention of filariasis. Horses: Treatment of parasites includes Strongyloides vulgaris and stomach robots such as the stomach and small intestine. Cattle: treatment of parasites such as gastrointestinal tract, nematode oyster and pneumoniasis placenta. Sheep: treatment of nematodes. Nematodes can develop cross-resistance between moxidin and other similar parasiticide agents, such as ivermectin, doramectin, and avermectin. Moxidin is being evaluated as a cure for eradication of scabies in humans, especially when they are resistant to other therapies. |
| clinical application | on June 13, 2018, FDA approved the Moxidectin of Medicines Development for Global Health (moxitin) for the treatment of onchocerciasis. Moxitin is a macrolide anthelmintic antibiotic, which has been published as early as the 60s, but the United States has not approved this product for human use, so Moxitin is also a typical new batch of old drugs. The main clinical feature of filariasis is that it is parasitic in the eyes or subcutaneous tissues. The main clinical feature is eye damage, which can cause blindness, so it is also called river blindness. In a clinical trial involving 1472 patients (NCT 00790998), 977 patients took moxitin and 475 patients took ivermectin. After one month of treatment, the average density of microfilariae in moxitin treatment group was 0.1, while that in ivermectin treatment group was 2.3[28]. After 12 months, the average density of microfilaria in moxitin treatment group was 1.79, while that in ivermectin treatment group was 9.83. River blindness is rare in developed countries, but it is very common in Africa. The approval of this product is undoubtedly a good news for African people. |
| biological activity | Moxidectin(ProHeart 6; CL301423; Cydectin) is an insect repellent that can be used to prevent and control heartworm and roundworm. |
Last Update：2024-04-09 20:13:35
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