Equisporol
GOSSYPETIN
CAS: 489-35-0
Molecular Formula: C15H10O8
Equisporol - Names and Identifiers
| Name | GOSSYPETIN |
| Synonyms | C.I.75750 Equisporol GOSSYPETIN Articulatidin GOSSYPETIN(RG) 8-Hydroxyquercetin 3,3',4',5,7,8-Hexahydroxyflavone 3,5,7,8,3',4'-HEXAHYDROXYFLAVONE 2-(3,4-Dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-1-benzopyran-4-one |
| CAS | 489-35-0 |
Equisporol - Physico-chemical Properties
| Molecular Formula | C15H10O8 |
| Molar Mass | 318.24 |
| Density | 1.912 |
| Melting Point | 302-304°C |
| Boling Point | 679.3±55.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)) |
| Appearance | Solid |
| Color | Dark Yellow |
| pKa | 6.47±0.40(Predicted) |
| Storage Condition | Hygroscopic, Refrigerator, under inert atmosphere |
Equisporol - Reference
| Reference Show more | 1. Zhang Diwen, Ma kaitianping. Simultaneous determination of 11 active components in jinniankui by UPLC-MS/MS [J]. Journal of Pharmaceutical Analysis, 2019, 039(005):780-786. 2. Dong Wang et al [IF = 4.162]. "Total Flavone of Abelmoschus manihot ameriorates Stress." Drug Des Dev Ther. 2021; 15: 2999-3016 |
Equisporol - Reference Information
| biological activity | gossypeetin is a hexahydroxylated flavonoid that is a potent MKK3 and MKK6 inhibitor, it can strongly attenuate the MKK3/6-p38 signaling pathway and has a variety of pharmacological activities, including antioxidant, antibacterial and anticancer activities. |
| Cell Line: | KYSE30, KYSE450 and KYSE510 cells KYSE30 and KYSE410 ccells KYSE450 and KYSE510 cells Esophageal cancer cells |
| Concentration: | 20 μM, 40 μM, 60 μM 60 μM 20 μM, 40 μM 20 μM, 40 μM |
| Incubation Time: | 48 hours 3 hours 48 hours 72 hours |
| Result: | Anchorage-dependent esophageal cancer cell growth was significantly inhibited. p38 activity was strongly inhibited in a dose-dependent manner. Reduced S phase and induces G2 phase cell cycle arrest in a dose-dependent manner. Induced apoptosis of esophageal cancer cells. Suppressed patient-derived esophageal xenograft tumor growth in an in vivo mouse model. |
| Animal Model: | Severe combined immunodeficiency (SCID) female mice (6-9 weeks old) injection with esophageal cancer tissue |
| Dosage: | 100 mg/kg |
| Administration: | Oral administration; 5 times per week; for 21 days |
Last Update：2024-04-09 21:54:55
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CAS: 489-35-0
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CAS: 489-35-0
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