Ethyl-2-(bis(2-oxooxazolidin-3-yl)phosphoryloxyimino)-2-cyanoacetate - Names and Identifiers
Ethyl-2-(bis(2-oxooxazolidin-3-yl)phosphoryloxyimino)-2-cyanoacetate - Physico-chemical Properties
| Melting Point | 164.5-166.3℃ |
| Appearance | White solid |
| Storage Condition | -Store at 20 ℃ |
Ethyl-2-(bis(2-oxooxazolidin-3-yl)phosphoryloxyimino)-2-cyanoacetate - Introduction
Ethyl-2-(bis(2-oxooxazolidin-3-yl) Ethyl-2)-2-cyanoacetate (bis(2-oxooxazolidin-3-yl)-2-cyanoacetate) is an organic compound commonly used as a coupling reagent in organic synthesis. The following is a description of the nature, use, preparation and safety information of Ethyl-2-(bis(2-oxooxazolidin-3-yl) phosphoxyimino)-2-cyanoacetate:
Nature:
-Appearance: Ethyl-2-(bis(2-oxooxazolidin-3-yl) phosphoxyimino)-2-cyanoacetate as a yellow to orange crystalline solid.
-Molecular formula: C12H15N3O7P
-Molecular weight: 337.24g/mol
-Melting Point: 110-115 ℃
-Solubility: Ethyl-2-(bis(2-oxooxazolidin-3-yl) phosphoxyimino)-2-cyanoacetate is soluble in some organic solvents (such as dimethylformamide, dichloromethane), but difficult to dissolve in water.
Use:
-coupling reagent: Ethyl-2-(bis(2-oxooxazolidin-3-yl) phosphoxyimino)-2-cyanoacetate is widely used as an excellent acylation reagent in organic synthesis and often reacts with activated substrates, to produce the acylated product.
-polypeptide synthesis: Ethyl-2-(bis(2-oxooxazolidin-3-yl) phosphoxyimino)-2-cyanoacetate is commonly used in the process of polypeptide synthesis to promote the coupling reaction between peptide segments.
Method:
Ethyl-2-(bis(2-oxooxazolidin-3-yl) phosphoxyimino)-2-cyanoacetate can be synthesized by the following steps:
1. 2-cyanoacetate (Ethyl 2-cyanoacetate) and diisopropyl carbamate (Boc-glycine) react under alkaline conditions to obtain dioxaazanone (2-oxooxazolidine).
2. The obtained 2-oxooxazolidine is reacted with DCC (dithiopropionic acid) and other reagents under acidic conditions to generate Ethyl-2-(bis(2-oxooxazolidin-3-yl) phosphoxyimino)-2-cyanoacetate.
Safety Information:
Ethyl-2-(bis(2-oxooxazolidin-3-yl)phosphoryloxyimino)-2-cyanoacetate is harmful to the human body and the environment to a certain extent, so you need to pay attention to safety measures when using and handling.
-use should wear protective glasses and gloves, avoid contact with skin and eyes.
-Prevent inhalation of aerosol or dust during operation.
-Avoid contact with flammable substances and strong oxidants.
-Store away from fire, heat and open flames.
-Waste Disposal: Dispose of in accordance with local regulations.
Please note that when using or handling Ethyl-2-(bis(2-oxooxazolidin-3-yl) phosphoxyimino)-2-cyanoacetate chemicals, you should strictly follow safe operating measures and consult a professional for guidance.
Last Update：2024-04-10 22:29:15