FEN1-IN-3
FEN1-IN-3
CAS: 2109805-87-8
Molecular Formula: C15H12N2O4
FEN1-IN-3 - Names and Identifiers
| Name | FEN1-IN-3 |
| Synonyms | FEN1-IN-3 FEN1 Inhibitor C3 3-Hydroxy-1-(4-methoxyphenyl)quinazoline-2,4(1H,3H)-dione 2,4(1H,3H)-Quinazolinedione, 3-hydroxy-1-(4-methoxyphenyl)- |
| CAS | 2109805-87-8 |
FEN1-IN-3 - Physico-chemical Properties
| Molecular Formula | C15H12N2O4 |
| Molar Mass | 284.27 |
| Appearance | Solid |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a , both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines. |
FEN1-IN-3 - Reference Information
| bioactivity | FEN1-IN-3 (Compound 4) is a human skin flap endonuclease 1 (hFEN1) inhibitor. hFEN1 was stabilized FEN1-IN-3 with an EC50 of 6.8 μm. |
Last Update：2024-04-09 15:16:57
Supplier List
Spot supply
Product Name: FEN1-IN-3 Visit Supplier Webpage Request for quotationCAS: 2109805-87-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: FEN1-IN-3 Visit Supplier Webpage Request for quotationCAS: 2109805-87-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: FEN1-IN-3 Visit Supplier Webpage Request for quotationCAS: 2109805-87-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: FEN1-IN-3 Visit Supplier Webpage Request for quotationCAS: 2109805-87-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: FEN1-IN-3 Visit Supplier Webpage Request for quotationCAS: 2109805-87-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: FEN1-IN-3 Visit Supplier Webpage Request for quotationCAS: 2109805-87-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
FEN1-IN-3
2-Trimethylsiloxypent-2-ene-4-one
4-Chloropyridine-2,6-dicarboxylic acid
5-溴-2-甲酰胺
2,4-二氯-5-三氟甲基嘧啶
Propyl heptanoate
Fmoc-R-3-Amino-3-(4-fluoro-phenyl)-propionic acid
Chloroacetyl chloride
Vinyl benzyl ether
右美沙芬杂质C
2-Trimethylsiloxypent-2-ene-4-one
4-Chloropyridine-2,6-dicarboxylic acid
5-溴-2-甲酰胺
2,4-二氯-5-三氟甲基嘧啶
Propyl heptanoate
Fmoc-R-3-Amino-3-(4-fluoro-phenyl)-propionic acid
Chloroacetyl chloride
Vinyl benzyl ether
右美沙芬杂质C