FEN1-IN-4
FEN1-IN-4
CAS: 1995893-58-7
Molecular Formula: C12H12N2O3
FEN1-IN-4 - Names and Identifiers
| Name | FEN1-IN-4 |
| Synonyms | FEN1-IN-4 FEN1 Inhibitor C2 1-(Cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione 2,4(1H,3H)-Quinazolinedione, 1-(cyclopropylmethyl)-3-hydroxy- |
| CAS | 1995893-58-7 |
FEN1-IN-4 - Physico-chemical Properties
| Molecular Formula | C12H12N2O3 |
| Molar Mass | 232.24 |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a , both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines. |
FEN1-IN-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.306 ml | 21.529 ml | 43.059 ml |
| 5 mM | 0.861 ml | 4.306 ml | 8.612 ml |
| 10 mM | 0.431 ml | 2.153 ml | 4.306 ml |
| 5 mM | 0.086 ml | 0.431 ml | 0.861 ml |
Last Update：2024-01-02 23:10:35
FEN1-IN-4 - Reference Information
| bioactivity | FEN1-IN-4 (Compound 2) is a human skin flap endonuclease 1 (hFEN1) inhibitor. |
| Target | hFEN1 |
Last Update：2024-04-09 21:54:55
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Product Name: FEN1-IN-4 Visit Supplier Webpage Request for quotationCAS: 1995893-58-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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