| Molecular Formula | C21H18Cl2N2O3 |
| Molar Mass | 417.29 |
| Physical and Chemical Properties | The chemical properties are yellow oily liquid, refractive index n25D1.5630, vapor pressure 2.05 × 10-4Pa (26 ℃), soluble in organic solvents, insoluble in water. The half-life at 50 ℃ is 4h (pH 7). |
| Use | Uses a broad-spectrum pyrethroid, gastric toxicity and contact killing effect. Control of cotton bollworm, cotton bollworm, small leaf roller moth and Cotton Whitefly has a good effect, the dosage of 0.8g/100. The product with stomach poison and killing effect, is a broad-spectrum insecticide, control of cotton bollworm, cotton bollworm, small leaf moth and Cotton Whitefly has a good effect. |
Toxicity
acute oral LD50460mg/kg in rats and 100~200 mg/kg in mice; Acute percutaneous LD50625mg/kg in rabbits; No irritation to rabbit skin and eyes. The subacute useless dose in rats is 50mg/kg. The Ames test was negative. Goldfish LC50 is 4.8 × 10-9.
production method
1, (1) preparation of 6-phenoxypyridine formaldehyde cyanohydrin Add a mixture of 0.61mol 6-phenoxypyridine formaldehyde and 0.73mol sodium bisulfite in 750ml of water, stir and dissolve, extract with dichloromethane to remove water insoluble matter, add 0.73mol sodium cyanide to the solution, react for 2 hours, and then extract with dichloromethane. The extract is washed with sodium bisul, add hexane, stir, filter and dry to obtain 6-phenoxypyridine formaldehyde cyanol white crystal with melting point of 84.5 ℃. (2) Preparation of Chlorpyrethrin 0.112mol 6-phenoxypyridine formaldehyde cyanide and 0.123mol 3-(2,2-dichlorovin)-2,2-dimethylcyclopropane carbonyl chloride (the ratio of cis and trans isomers is 40:60), add 300ml of anhydrous ethanol ether, cool to 0 ℃ in an ice bath, slowly add 25ml of triethylamine, stir for 2, let stand, separate the organic layer, and then wash with water, dilute hydrochloric acid, dilute lye, after drying, concentration, reduced pressure distillation to collect 125 ℃(6.65Pa) low boiling point fraction, get yellow oil, namely chlorpyridine crude oil.
2. preparation method 1
preparation of 6-phenoxypyridine formaldehyde cyanol Add a mixture of 0.61 mol6-phenoxypyridine formaldehyde and 0.73mol sodium bisulfite in 750mL of water, stir and dissolve, extract with dichloromethane to remove water insoluble matter, then add a mixture of 0.73mol sodium bisulfate, react for 2 hours, and then extract with dichloromethane. The extract is washed with sodium bisulfite aqueous solution, dried, add hexane, stir and dry to obtain 6-phenoxypyridine formaldehyde cyanohydrin with a melting point of 84.5 ℃.
synthesis of permethrin 0.112mol phenoxy pyridine formaldehyde cyanide and 0.123mol dichlorochrysanthemum chloride (cis: trans = 4:6), added to 300mL of anhydrous diethyl ether, cooled to 0 ℃ in ice bath, slowly added 25mL of triethylamine, stirred for reaction for 2 hours, heated to room temperature at the same time, diluted with water, let stand, separated, washed with water, the 125 ℃/6.65Pa fraction was collected under reduced pressure to obtain yellow oil, namely pyridine-cypermethrin crude oil.
Preparation method II
Cypermethrin can also be synthesized by dichlorochrysanthemum chloride, 6-phenoxypyridine formaldehyde and sodium cyanide in the presence of a phase transfer catalyst.