Molecular Formula | C25H30N2O5
|
Molar Mass | 438.52 |
Density | 1.25±0.1 g/cm3(Predicted) |
Melting Point | 199-202oC |
Boling Point | 597.5±50.0 °C(Predicted) |
Solubility | DMSO: soluble5mg/mL, clear (warmed) |
Appearance | powder |
Color | white to beige |
pKa | 0.78±0.70(Predicted) |
Storage Condition | 2-8°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. |
In vitro study | In Hela cells overexpressing Notch green fluorescent protein, FLI-06 inhibited the transport and treatment of Notch. FLI-06 change the maturation pattern of APP and terminate the release of APPs. In renal epithelial cell line 293 cells, stable transfection of mutant APP resulted in extensive amyloid precipitation. FLI-06 destruction of the Golgi complex, in the endoplasmic reticulum from tubular to patchy form of the transformation process, inhibition of endoplasmic reticulum transport before the secretion of total protein. |
In vivo study | In zebrafish embryos, FLI-06 of 50um inhibited endogenous Notch signaling. |