FMOC-3-(TRIFLUOROMETHYL)-L-PHENYLALANINE

FMOC-3-(TRIFLUOROMETHYL)-L-PHENYLALANINE - Names and Identifiers

Name	Fmoc-L-3-Trifluoromethylphenylalanine
Synonyms	FMOC PROTECTED Fmoc-L-3-CF3-Phe Fmoc-Phe(3-CF3)-OH Fmoc-L-3-Trifluoromethylphe Fmoc-L-Phe(3-trifluoromethyl)-OH Fmoc-L-3-Trifluoromethylphenylalanine Fmoc-3-Trifluoromethyl-L-phenylalanine FMOC-3-(TRIFLUOROMETHYL)-L-PHENYLALANINE fluorenylmethoxycarbonyl-l-3-trifluoromethylphenylalanine Fluorenylmethoxycarbonyl-L-3-trifluoromethylphenylalanine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(trifluoromethyl)-L-phenylalanine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(trifluoromethyl)-D-phenylalanine N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(trifluoromethyl)-L-phenylalanine (2S)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[3-(trifluoromethyl)phenyl]propanoic acid
CAS	205526-27-8
InChI	InChI=1/C25H20F3NO4/c26-25(27,28)16-7-5-6-15(12-16)13-22(23(30)31)29-24(32)33-14-21-19-10-3-1-8-17(19)18-9-2-4-11-20(18)21/h1-12,21-22H,13-14H2,(H,29,32)(H,30,31)/t22-/m0/s1

FMOC-3-(TRIFLUOROMETHYL)-L-PHENYLALANINE - Physico-chemical Properties

Molecular Formula	C25H20F3NO4
Molar Mass	455.43
Density	1.351±0.06 g/cm3(Predicted)
Melting Point	147-157°C
Boling Point	611.2±55.0 °C(Predicted)
Flash Point	323.5°C
Vapor Presure	8.56E-16mmHg at 25°C
pKa	3.68±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.587

FMOC-3-(TRIFLUOROMETHYL)-L-PHENYLALANINE - Risk and Safety

Hazard Symbols	Xi - Irritant
WGK Germany	3
Hazard Note	Harmful/Irritant/Keep Cold
Hazard Class	IRRITANT

FMOC-3-(TRIFLUOROMETHYL)-L-PHENYLALANINE - Introduction

Fmoc-L-3-Trifluoromethylphenylalanine is a compound that has the following properties:

1. Physical properties: Fmoc-L-3-Trifluoromethylphenylalanine is a white crystalline powder, soluble in organic solvents such as dichloromethane, dimethyl sulfoxide and ether, insoluble in water.

2. Chemical properties: It is an amino acid protecting group that can be used in solid phase synthesis. Its amino acid side chain contains a trifluoromethylphenyl group, which provides protection and is removed when desired.

Fmoc-L-3-Trifluoromethylphenylalanine uses mainly include:

1. Solid phase synthesis: as a protecting group in solid phase synthesis, for the synthesis of peptides and proteins.

2. Chemical biology research: for the synthesis of drug molecules and bioactive peptides for drug research and development.

The method of preparing Fmoc-L-3-Trifluoromethylphenylalanine usually involves the following steps:

1. L-3-trifluoromethylphenylalanine reacts with Fmoc-Cl (fluoroformylphenyl chloride) to generate Fmoc-L-3-Trifluoromethylphenylalanine.

2. Purify the product by crystallization or column chromatography to obtain a high-purity Fmoc-L-3-Trifluoromethylphenylalanine.

When using or handling Fmoc-L-3-Trifluoromethylphenylalanine, please note the following safety information:

1. Fmoc-L-3-Trifluoromethylphenylalanine should be stored in a cool, dry place, avoid direct sunlight.

2. Wear appropriate personal protective equipment such as lab gloves and safety glasses during operation.

3. Avoid contact with skin and inhalation of dust.

4. Fmoc-L-3-Trifluoromethylphenylalanine for chemical reagents, should be used in accordance with the safety procedures, to avoid eating.

5. In the process of treatment, correct laboratory operation methods should be followed to avoid accidents and pollution.

Last Update：2024-04-09 18:58:34