FMOC-D-3-氨基-3-(4-氟苯基)丙酸

FMOC-D-3-氨基-3-(4-氟苯基)丙酸 - Names and Identifiers

Name	Fmoc-R-3-Amino-3-(4-fluoro-phenyl)-propionic acid
Synonyms	FMOC-D-BETA-PHE(4-F)-OH FMOC-PHG(4-F)-(C*CH2)OH FMOC-(R)-4-FLUORO-BETA-PHENYLALANINE FMOC PROTECTED (R)-B-(P-FLUOROPHENYL)-B-ALANINE Fmoc-R-3-Amino-3-(4-fluoro-phenyl)-propionic acid FMOC-(R)-3-AMINO-3-(4-FLUORO-PHENYL)-PROPANOIC ACID FMOC-(R)-3-AMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID N-BETA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-L-HOMO(4-FLUOROPHENYL)GLYCINE (R)-3-(9-FLUORENYLMETHOXYCARBONYLAMINO)-3-(4-FLUORO-PHENYL)-PROPIONIC ACID
CAS	479064-95-4
EINECS	200-258-5

FMOC-D-3-氨基-3-(4-氟苯基)丙酸 - Physico-chemical Properties

Molecular Formula	C24H20FNO4
Molar Mass	405.42
Density	1.316±0.06 g/cm3(Predicted)
Boling Point	617.6±55.0 °C(Predicted)
pKa	4.26±0.10(Predicted)
Storage Condition	2-8°C

FMOC-D-3-氨基-3-(4-氟苯基)丙酸 - Introduction

Fmoc-R-3-Amino-3-(4-fluoro-phenyl)-propionic acid is an organic compound with the following properties:

Nature:
-Appearance: Colorless crystalline or powdery solid
-Molecular formula: C22H17FNO3
-Molecular weight: 369.37g/mol
-Melting point: 173-176°C
-Solubility: Soluble in many organic solvents, such as dimethylthionamide (DMSO), chloroform and dichloromethane.

Use:
- Fmoc-R-3-Amino-3-(4-fluoro-phenyl)-propionic acid is commonly used as a protecting group in solid phase synthesis, and can be used for the introduction of amino acids and the synthesis of polypeptides in solid phase synthesis methods.
-It can also be used as a reagent in drug research and biochemical research to synthesize ligands and drugs with specific biological activities.

Preparation Method:
There are many preparation methods for Fmoc-R-3-Amino-3-(4-fluoro-phenyl)-propionic acid. The commonly used methods include the following steps:
1. Reaction of Fmoc-acid with R-3-amino -3-(4-fluorophenyl) propanol in a suitable solvent.
2. after the reaction, an acidic solution was added for neutralization, and the obtained solid product was collected.
3. carry out crystallization or column chromatography purification to obtain pure Fmoc-R-3-amino -3-(4-fluorophenyl) propionic acid product.

Safety Information:
- Fmoc-R-3-Amino-3-(4-fluoro-phenyl)-propionic acid may be irritating to the eyes and skin, and care should be taken to avoid contact with eyes and skin.
-During operation, follow laboratory safety procedures and wear appropriate personal protective equipment, such as laboratory gloves and eye protection.
-During storage and use, it should be kept in a dry, cool place, away from fire and oxidizing agents.
-If necessary, operate in a well-ventilated place to avoid inhaling dust or gas from the product.

Last Update：2024-04-09 02:00:49

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