FMOC-D-HISTIDINE(FMOC)-OH - Names and Identifiers
FMOC-D-HISTIDINE(FMOC)-OH - Physico-chemical Properties
Molecular Formula | C36H29N3O6
|
Molar Mass | 599.63 |
Density | 1.38±0.1 g/cm3(Predicted) |
Melting Point | 144-155°C |
pKa | 12.26±0.46(Predicted) |
Storage Condition | Sealed in dry,2-8°C |
FMOC-D-HISTIDINE(FMOC)-OH - Introduction
Fmoc-D-His(Fmoc)-OH is a chemical reagent with many properties and uses. Here is an introduction about it:
Nature:
Fmoc-D-His(Fmoc)-OH is a colorless solid with a chemical formula of C34H30F2N2O7 and a relative molecular mass of 606.61g/mol. It is an important amino acid derivative and is widely used in biochemistry and organic synthesis. It has high solubility and is easily dissolved in organic solvents.
Use:
Fmoc-D-His(Fmoc)-OH is commonly used as a protecting group in solid phase synthesis. It can be used in the synthesis of polypeptides and proteins by the reaction of deprotecting groups to introduce D-histidine residues. It can also be used to study the structure and function of peptides, as well as to develop new drugs and biochemical tools.
Method:
The synthesis of Fmoc-D-His(Fmoc)-OH can be carried out by the reaction of the N-protecting Group of the amino acid D-histidine. A common method is to react D-histidine with Fmoc-NH2 (n-carbonyl-9-fluoromethylurea) under basic conditions to give Fmoc-D-His(Fmoc)-OH.
Safety Information:
Fmoc-D-His(Fmoc)-OH, as a chemical reagent, needs to be operated in accordance with laboratory safety procedures. It has a certain irritation and toxicity, should avoid contact with the skin and eyes. Wear appropriate personal protective equipment such as lab gloves and goggles during use. When storing and handling, it should be kept in a sealed container, away from open flames and oxidizing agents. If accidental splashing or inhalation occurs, rinse immediately with clean water and seek medical help as needed.
Last Update:2024-04-09 15:17:54