Name | Fmoc-D-Phenylalanine |
Synonyms | FmocAV21690 Fmoc-D-Phe-OH Fmoc-D-Phc-OH Fmoc-D-Phenylalanine FMOC-D-Phenylalanine-OH FMOC-D-PHENYLALANINE extrapure FMoc-D-Phe-OH FMoc-D-Phenylalanine N-Fmoc-D-phenylalanineFmoc-D-Phe-OH N-fluorenylmethoxycarbonyl-D-phenylalanine N-(9-Fluorenylmethoxycarbonyl)-D-phenylalanine NALPHA-9-Fluorenylmethoxycarbonyl-D-phenylalanine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine D-Phenylalanine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]- (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-phenylpropanoate (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropanoic acid (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropanoic acid |
CAS | 86123-10-6 |
EINECS | 1533716-785-6 |
InChI | InChI=1/C24H21NO4/c26-23(27)22(14-16-8-2-1-3-9-16)25-24(28)29-15-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h1-13,21-22H,14-15H2,(H,25,28)(H,26,27)/p-1/t22-/m1/s1 |
InChIKey | SJVFAHZPLIXNDH-JOCHJYFZSA-N |
Molecular Formula | C24H21NO4 |
Molar Mass | 387.43 |
Density | 1.276±0.06 g/cm3(Predicted) |
Melting Point | 181-185°C |
Boling Point | 620.1±50.0 °C(Predicted) |
Specific Rotation(α) | 38 ° (C=1, DMF) |
Flash Point | 328.8°C |
Vapor Presure | 3.07E-16mmHg at 25°C |
Appearance | Crystallization |
Color | White |
BRN | 4767931 |
pKa | 3.77±0.10(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 38 ° (C=1, DMF) |
MDL | MFCD00062955 |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
FLUKA BRAND F CODES | 10-21 |
HS Code | 29242990 |
Introduction | Fmoc-D-Phenylalanine is white to off-white solid powder at normal temperature and pressure, Fmoc-D-Phenylalanine is soluble in dimethyl sulfoxide, organic solvents such as N,N-dimethylformamide. They are useful as intermediates in chiral organic synthesis. |
Use | Fmoc-D-Phenylalanine is an intermediate in chiral organic synthesis, the main purpose is to participate in the synthesis of chiral drug molecules and bioactive molecules as molecular backbones. Fmoc-D-phenylalanine and psychotropic drugs related to the preparation of amphetamine derivatives, therefore the compounds are prohibited from marketing. |
synthesis method | for 3-(2-chloroethyl)-6,7,8, synthesis of 9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido [1,2-a] pyrimidin-4-one, starting from 2-amino-3-benzyloxypyridine and under the action of trichlorophosphine oxide, the target product of benzyl protection of hydroxyl group is obtained by one-step condensation reaction; then the benzyl group is removed under the condition of hydrogenation of palladium on carbon to obtain 3-(2-chloroethyl)-6,7,8, 9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido [1,2-a] pyrimidin-4-one. It should be noted that in the process of hydrogenation of palladium and carbon, the pressure of hydrogen used is one atmosphere, and better reaction results can be obtained under heating conditions. |