D-Tyrosine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-is a compound with a specific structure and has the following properties:
1. Appearance: White to yellowish crystalline solid.
2. Molecular formula: C25H23IN2O4.
3. Molecular weight: 540.37g/mol.
4. Melting point: About 180-184 ° C.
5. Storage conditions: should be stored in a cold dark place, avoid prolonged exposure to air and light.
D-Tyrosine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-is mainly used in peptide synthesis and protein engineering in solid phase synthesis (SPPS). Its introduction as a protecting group (Fmoc) enables it to be protected and deprotected during the synthesis process, thereby effectively controlling the position and sequence of the synthesis reaction.
D-Tyrosine, the preparation method of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-mainly includes the following steps:
1. First, iodotyrosine is reacted with excess sodium hydroxide under hydrogenation reaction conditions to obtain D-3-iodotyrosine.
2. Then, N-[(9H-fluoren-9-ylmethoxy)carbonyl] imine (Fmoc-Osu) was added to iodotyrosine for acylation to give D-Tyrosine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-.
Regarding safety information, you need to pay attention to the following:
1. D-Tyrosine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-is a chemical reagent used in the laboratory and can only be used in an environment equipped with chemical laboratory safety facilities.
2. Use should pay attention to protective measures, such as wearing appropriate protective glasses, gloves and laboratory clothes.
3. Avoid inhaling its dust, avoid contact with skin and eyes, and ensure good ventilation during operation and storage.
4. If accidentally touched or inhaled, should immediately rinse with plenty of water, and consult a doctor.