FMOC-DL-NORLEUCINE
Fmoc-DL-Nle-OH
CAS: 144701-20-2
Molecular Formula: C21H23NO4
FMOC-DL-NORLEUCINE - Names and Identifiers
FMOC-DL-NORLEUCINE - Physico-chemical Properties
| Molecular Formula | C21H23NO4 |
| Molar Mass | 353.41 |
| Density | 1.209±0.06 g/cm3(Predicted) |
| Boling Point | 565.6±33.0 °C(Predicted) |
| pKa | 3.91±0.21(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
FMOC-DL-NORLEUCINE - Introduction
Fmoc-DL-Nle-OH is a commonly used amino acid protecting group. Its chemical name is 9-fluoroketo-2, 3-naphthalenedicarboxylic acid-N-bright carbamoylcarbamic acid. The following is a description of the nature, use, preparation and safety information of the Fmoc-DL-Nle-OH:
Nature:
Fmoc-DL-Nle-OH is a white to off-white solid that is soluble in most organic solvents, such as dimethyl sulfoxide, methanol, and methylene chloride. It has good thermal stability and is not easy to decompose at high temperature.
Use:
Fmoc-DL-Nle-OH is commonly used as a protecting group in peptide synthesis and solid phase synthesis in chemical synthesis. It can protect the amino groups of amino acids to prevent side reactions during synthesis. In peptide synthesis, it is commonly used to synthesize D-or L-norleucine residues in polypeptide chains.
Method:
The preparation of Fmoc-DL-Nle-OH usually adopts organic synthesis method. A common synthetic route is to react norleucine with Fmoc-leucine ester to generate Fmoc-leucine-norleucine ester, which is then hydrolyzed to obtain Fmoc-DL-Nle-OH.
Safety Information:
The use of Fmoc-DL-Nle-OH should follow laboratory safety procedures. It is relatively safe under normal conditions, but it still needs to be handled carefully as a chemical. Avoid inhalation, contact with skin and eyes. Wear protective gloves and goggles. Use and store away from ignition and oxidizing agents. If exposed or ingested, seek medical attention immediately.
Nature:
Fmoc-DL-Nle-OH is a white to off-white solid that is soluble in most organic solvents, such as dimethyl sulfoxide, methanol, and methylene chloride. It has good thermal stability and is not easy to decompose at high temperature.
Use:
Fmoc-DL-Nle-OH is commonly used as a protecting group in peptide synthesis and solid phase synthesis in chemical synthesis. It can protect the amino groups of amino acids to prevent side reactions during synthesis. In peptide synthesis, it is commonly used to synthesize D-or L-norleucine residues in polypeptide chains.
Method:
The preparation of Fmoc-DL-Nle-OH usually adopts organic synthesis method. A common synthetic route is to react norleucine with Fmoc-leucine ester to generate Fmoc-leucine-norleucine ester, which is then hydrolyzed to obtain Fmoc-DL-Nle-OH.
Safety Information:
The use of Fmoc-DL-Nle-OH should follow laboratory safety procedures. It is relatively safe under normal conditions, but it still needs to be handled carefully as a chemical. Avoid inhalation, contact with skin and eyes. Wear protective gloves and goggles. Use and store away from ignition and oxidizing agents. If exposed or ingested, seek medical attention immediately.
Last Update：2024-04-09 02:00:42
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CAS: 144701-20-2
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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CAS: 144701-20-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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