FMOC-HIS(FMOC)-OH
N(alpha),N(im)-di-fmoc-L-histidine
CAS: 98929-98-7
Molecular Formula: C36H29N3O6
FMOC-HIS(FMOC)-OH - Names and Identifiers
| Name | N(alpha),N(im)-di-fmoc-L-histidine |
| Synonyms | FMOC-HIS(FMOC)-OH Fmoc-His(Fmoc)-OH FMOC-L-HIS(FMOC)-OH NIM-DI-FMOC-L-HISTIDINE FMOC-HISTIDINE(FMOC)-OH N,1-Bis-Fmoc-L-histidine N-α,N-im-di-Fmoc-L-histidine N-ALPHA,IM-BIS-FMOC-L-HISTIDINE N-ALPHA,NIM-DI-FMOC-L-HISTIDINE N(alpha),N(im)-di-fmoc-L-histidine N,N'-BIS(9-FLUORENYLMETHYLOXYCARBONYL)-L-HISTIDINE N,N'-Bis(9-Fluorenylmethyloxycarbonyl)-L-Histidine N,3-bis[(9H-fluoren-9-ylmethoxy)carbonyl]-L-histidine N-ALPHA,N-TAU-DI-(9-FLUORENYLMETHOXYCARBONYL)-L-HISTIDINE |
| CAS | 98929-98-7 |
| EINECS | 202-716-0 |
| InChI | InChI=1/C36H29N3O6/c40-34(41)33(38-35(42)44-19-31-27-13-5-1-9-23(27)24-10-2-6-14-28(24)31)17-22-18-37-21-39(22)36(43)45-20-32-29-15-7-3-11-25(29)26-12-4-8-16-30(26)32/h1-16,18,21,31-33H,17,19-20H2,(H,38,42)(H,40,41)/t33-/m0/s1 |
FMOC-HIS(FMOC)-OH - Physico-chemical Properties
| Molecular Formula | C36H29N3O6 |
| Molar Mass | 599.63 |
| Density | 1.38±0.1 g/cm3(Predicted) |
| Melting Point | 144-155°C |
| pKa | 12.26±0.46(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.696 |
FMOC-HIS(FMOC)-OH - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| HS Code | 29242990 |
FMOC-HIS(FMOC)-OH - Introduction
N(alpha),N(im)-di-fmoc-L-histidine(N(alpha),N(im)-di-fmoc-L-histidine) is a compound obtained by the chemical reaction of 9-fluorenecinol and L-histidine. Its chemical formula is C42H38N4O8 and its relative molecular mass is 722.78g/mol.
N(alpha),N(im)-di-fmoc-L-histidine is a compound that protects amino acids and is widely used in organic synthesis and biochemical reactions. It is mainly used to regulate protein structure and function, as well as to expand and improve the application range of polypeptide chains. This compound is widely used in solid phase synthesis techniques for modifying the N-terminus and histidine residues of peptide and protein molecules.
The method of preparing N(alpha),N(im)-di-fmoc-L-histidine usually involves three steps. First, ethylene glycol dimethyl ether and diazotoluene were reacted under the catalysis of cuprous chloride to synthesize 9-fluorenmethanol. Then, 9-fluorenecinol and L-histidine are reacted under acidic conditions to obtain N(alpha),N(im)-di-fmoc-L-histidine. Finally, the pure product is obtained by crystallization and purification steps.
Regarding safety information, N(alpha),N(im)-There are not many relevant research reports on the specific safety of di-fmoc-L-histidine, so caution is required. When used in the laboratory, appropriate safety measures should be taken, including wearing appropriate protective equipment, such as laboratory gloves and glasses, and avoiding contact with skin and eyes. At the same time, it should be stored in a dry, ventilated and closed container, away from fire and combustible materials. For detailed safety information, it is recommended to consult the relevant literature or consult a professional.
N(alpha),N(im)-di-fmoc-L-histidine is a compound that protects amino acids and is widely used in organic synthesis and biochemical reactions. It is mainly used to regulate protein structure and function, as well as to expand and improve the application range of polypeptide chains. This compound is widely used in solid phase synthesis techniques for modifying the N-terminus and histidine residues of peptide and protein molecules.
The method of preparing N(alpha),N(im)-di-fmoc-L-histidine usually involves three steps. First, ethylene glycol dimethyl ether and diazotoluene were reacted under the catalysis of cuprous chloride to synthesize 9-fluorenmethanol. Then, 9-fluorenecinol and L-histidine are reacted under acidic conditions to obtain N(alpha),N(im)-di-fmoc-L-histidine. Finally, the pure product is obtained by crystallization and purification steps.
Regarding safety information, N(alpha),N(im)-There are not many relevant research reports on the specific safety of di-fmoc-L-histidine, so caution is required. When used in the laboratory, appropriate safety measures should be taken, including wearing appropriate protective equipment, such as laboratory gloves and glasses, and avoiding contact with skin and eyes. At the same time, it should be stored in a dry, ventilated and closed container, away from fire and combustible materials. For detailed safety information, it is recommended to consult the relevant literature or consult a professional.
Last Update：2024-04-10 22:29:15
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CAS: 98929-98-7
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CAS: 98929-98-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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