FMOC-L-ASN(TRT)-OPFP
Fmoc-Asn(Trt)-OPfp
CAS: 132388-64-8
Molecular Formula: C44H31F5N2O5
FMOC-L-ASN(TRT)-OPFP - Names and Identifiers
| Name | Fmoc-Asn(Trt)-OPfp |
| Synonyms | FMOC-ASN(TRT)-OPFP Fmoc-Asn(Trt)-OPfp FMOC-L-ASN(TRT)-OPFP FMOC-ASPARAGINE(TRT)-OPFP FMOC-N-BETA-TRITYL-L-ASPARAGINE PENTAFLUOROPHENYL ESTER FMOC-N-GAMMA-TRITYL-L-ASPARAGINE PENTAFLUOROPHENYL ESTER N-ALPHA-FMOC-N-BETA-TRITYL-L-ASPARAGINE PENTAFLUORPHENYL ESTER N-ALPHA-FMOC-N-BETA-TRITYL-L-ASPARAGINE PENTAFLUOROPHENYL ESTER NALPHA-9-Fluorenylmethoxycarbonyl-NB-trityl-L-asparagine pentafluorophenyl N-alpha-(9-fluorenylmethyloxycarbonyl)-N-beta-trityl-L-asparagine pentafluorphenyl ester Aspartic acid,(2,3,4,5,6-pentafluorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(trityliminomethoxy)propanoate |
| CAS | 132388-64-8 |
| InChI | InChI=1/C44H31F5N2O5/c45-36-37(46)39(48)41(40(49)38(36)47)56-42(52)35(51-43(53)55-24-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34)25-54-26-50-44(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29/h1-23,26,34-35H,24-25H2,(H,51,53)/t35-/m0/s1 |
FMOC-L-ASN(TRT)-OPFP - Physico-chemical Properties
| Molecular Formula | C44H31F5N2O5 |
| Molar Mass | 762.72 |
| Density | 1.358±0.06 g/cm3(Predicted) |
| Boling Point | 888.2±65.0 °C(Predicted) |
| Specific Rotation(α) | -7 º (C=1 IN DIOXANE) |
| Flash Point | 445.6°C |
| Vapor Presure | 1.61E-26mmHg at 25°C |
| Appearance | White powder |
| pKa | 9.80±0.46(Predicted) |
| Storage Condition | Store at -15°C to -25°C. |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.6 |
| MDL | MFCD00153373 |
FMOC-L-ASN(TRT)-OPFP - Risk and Safety
| WGK Germany | WGK 2 water endanger |
| HS Code | 2924 29 70 |
FMOC-L-ASN(TRT)-OPFP - Reference Information
| background | amino acids are well-known as a wide range of neutral substances. due to their amino and carboxyl groups, amino acids have amphoteric properties and can form intermolecular interactions with other substances. Asparagine has a very important biological significance because it is one of the basic components of 20 amino acids and many proteins in organisms. |
| preparation | (1) 25kg of maleic anhydride waste residue is added into 200 l of tap water, heated to 85 ℃ to dissolve the waste residue, filtered to remove insoluble substances, added 0.5kg of thiourea, adjusted the pH of the system to 3 with hydrochloric acid, heated and refluxed for 2.5 h, cooled and crystalliated, and filtered to obtain 17.6kg of solid. (2) Heat the 17.6kg of solid obtained above to 90 ℃ with 180kg of tap water to dissolve it, add 2kg of activated carbon, heat and reflux for 1 hour to decolorize, filter and remove impurities while hot, adjust the pH of the filtrate to 10 with ammonia water, add 44g of Escherichia coli to the filtrate, adjust the pH to 6 with 10wt% hydrochloric acid solution after 5 hours of reaction, cool and precipitate, and filter to obtain 15.7kg of solid. (3) The obtained 15.7kg of solid is soaked in 157kg of ethanol at 20 ℃ for 5 hours, and 5.8kg of crystals are filtered to obtain. The obtained crystals are baked at 80 ℃ for 8 hours to obtain 4.9kg of product, namely asparagine, with HPLC content of 97.4%. |
Last Update：2024-04-09 20:02:46
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