FMOC-L-DAP(ALLOC)-OH
Fmoc-Dap(Aloc)-OH
CAS: 188970-92-5
Molecular Formula: C22H22N2O6
FMOC-L-DAP(ALLOC)-OH - Names and Identifiers
| Name | Fmoc-Dap(Aloc)-OH |
| Synonyms | Fmoc-Dap(Alloc) FMOC-DPR(ALOC)-OH FMOC-DAP(ALOC)-OH Fmoc-Dap(Aloc)-OH Fmoc-Dap(Alloc)-OH FMOC-DAP(ALLOC)-OH FMOC-L-DAP(ALLOC)-OH FMOC-L-DAPA(ALLOC)-OH Fmoc-3-[[(Allyloxy)carbonyl]amino]-L-alanine FMOC-ALPHA,BETA-DIAMINOPROPIONIC ACID(ALOC)-OH N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-{[(prop-2-en-1-yloxy)carbonyl]amino}-L-alanine Nα-Fmoc-Nβ-Alloc-L-2,3-diaminopropionic acid, Nβ-Alloc-Nα-Fmoc-L-2,3-diaminopropionic acid, Nβ-Allyloxycarbonyl-Nα-Fmoc-L-2,3-diaminopropionic acid |
| CAS | 188970-92-5 |
| InChI | InChI=1/C22H22N2O6/c1-2-11-29-21(27)23-12-19(20(25)26)24-22(28)30-13-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h2-10,18-19H,1,11-13H2,(H,23,27)(H,24,28)(H,25,26)/t19-/m0/s1 |
FMOC-L-DAP(ALLOC)-OH - Physico-chemical Properties
| Molecular Formula | C22H22N2O6 |
| Molar Mass | 410.42 |
| Density | 1.298±0.06 g/cm3(Predicted) |
| Melting Point | 165 °C |
| Boling Point | 658.6±55.0 °C(Predicted) |
| Flash Point | 352.1°C |
| Vapor Presure | 3.04E-18mmHg at 25°C |
| Appearance | Solid |
| pKa | 3.56±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.595 |
FMOC-L-DAP(ALLOC)-OH - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
FMOC-L-DAP(ALLOC)-OH - Introduction
Fmoc-Dap(Aloc)-OH (also known as Fmoc-L-acetyl-beta-alanine) is an organic compound commonly used in peptide chemistry. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
1. Appearance: Usually a white crystalline solid.
2. Solubility: Soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM).
3. Melting Point: about 40-45 ℃.
4. Storage conditions: should be sealed and stored in a dry, cool place, away from light and fire.
Use:
1. Peptide synthesis: Fmoc-Dap(Aloc)-OH is one of the commonly used amino acid protecting groups, which can be used to synthesize peptide chains.
2. Medicinal chemistry: the compound can be used to synthesize drugs, peptide drugs and anti-tumor drugs.
Method:
Fmoc-Dap(Aloc)-OH can be prepared by the following steps:
1. First, Fmoc-β-alanine is reacted with acetic anhydride in the presence of dimethyl sulfoxide (DMSO) to prepare Fmoc-L-acetyl-β-alanine.
2. Then, Fmoc-L-acetyl-β-alanine is reacted with propenyl chloride under alkaline conditions to generate Fmoc-Dap(Aloc)-OH.
Safety Information:
1. Fmoc-Dap(Aloc)-OH is a laboratory compound and should be operated under appropriate laboratory conditions.
2. Use should wear appropriate personal protective equipment, such as gloves and goggles.
3. Avoid contact with skin, eyes and respiratory tract, such as accidental contact should immediately rinse with plenty of water.
4. In the storage and handling should pay attention to prevent the dust of the compound, and away from the flame and oxidant.
Nature:
1. Appearance: Usually a white crystalline solid.
2. Solubility: Soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM).
3. Melting Point: about 40-45 ℃.
4. Storage conditions: should be sealed and stored in a dry, cool place, away from light and fire.
Use:
1. Peptide synthesis: Fmoc-Dap(Aloc)-OH is one of the commonly used amino acid protecting groups, which can be used to synthesize peptide chains.
2. Medicinal chemistry: the compound can be used to synthesize drugs, peptide drugs and anti-tumor drugs.
Method:
Fmoc-Dap(Aloc)-OH can be prepared by the following steps:
1. First, Fmoc-β-alanine is reacted with acetic anhydride in the presence of dimethyl sulfoxide (DMSO) to prepare Fmoc-L-acetyl-β-alanine.
2. Then, Fmoc-L-acetyl-β-alanine is reacted with propenyl chloride under alkaline conditions to generate Fmoc-Dap(Aloc)-OH.
Safety Information:
1. Fmoc-Dap(Aloc)-OH is a laboratory compound and should be operated under appropriate laboratory conditions.
2. Use should wear appropriate personal protective equipment, such as gloves and goggles.
3. Avoid contact with skin, eyes and respiratory tract, such as accidental contact should immediately rinse with plenty of water.
4. In the storage and handling should pay attention to prevent the dust of the compound, and away from the flame and oxidant.
Last Update：2024-04-09 21:01:54
