FPS-ZM1
N-benzyl-4-chloro-N-cyclohexylbenzaMide
CAS: 945714-67-0
Molecular Formula: C20H22ClNO
FPS-ZM1 - Names and Identifiers
FPS-ZM1 - Physico-chemical Properties
| Molecular Formula | C20H22ClNO |
| Molar Mass | 327.85 |
| Density | 1.18±0.1 g/cm3(Predicted) |
| Boling Point | 497.6±38.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 20 mg/ml) |
| Appearance | solid |
| Color | Off-white |
| pKa | -1.54±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| In vitro study | FPS-ZM1 prevents Aβ from binding to the V region of RAGE and inhibits Aβ40-and Aβ42-induced cellular stress in RAGE-expressing cells. It also inhibits the binding of other ligands to RAGE, such as S100B,AGE, and HMGB1, which may be involved in RAGE-mediated long-term tissue damage (in diabetic models), immune/inflammatory diseases, Alzheimer's disease, etc. |
| In vivo study | FPS-ZM1 is not toxic to mice and can pass the blood brain barrier. It inhibits RAGE in the brain and the blood-brain barrier in 17-month-old APPsw/0 mice with Aβ and amyloid lesions, effectively controls Aβ-mediated brain disease, related neurovascular and Cognitive Disorder progression. |
FPS-ZM1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.05 ml | 15.251 ml | 30.502 ml |
| 5 mM | 0.61 ml | 3.05 ml | 6.1 ml |
| 10 mM | 0.305 ml | 1.525 ml | 3.05 ml |
| 5 mM | 0.061 ml | 0.305 ml | 0.61 ml |
Last Update：2024-01-02 23:10:35
FPS-ZM1 - Reference Information
| Biological activity | FPS-ZM1 is a non-toxic, tertiary amide compound that can penetrate the blood and brain barrier. It is a specific inhibitor of RAGE and inhibits the binding of Aβ to the V region of RAGE. |
| target | TargetValue RAGE |
| Target | Value |
| In vitro study | FPS-ZM1 prevent Aβ from binding to the V region of RAGE, and inhibit Aβ40-and Aβ42-induced cell stress in RAGE-expressing cells. It also inhibits the binding of other ligands to RAGE, such as S100B,AGE and HMGB1. These ligands bind to RAGE and may be involved in RAGE-mediated long-term tissue damage (in diabetes models), immune/inflammatory diseases, Alzheimer's disease, etc. |
| in vivo research | FPS-ZM1 is non-toxic to mice and can pass through the blood-brain barrier. It can effectively control the development of Aβ-mediated brain diseases, related neurovascular and cognitive disorders by inhibiting RAGE in the brain and blood-brain barrier in 17-month-old APPsw/0 mice with Aβ and amyloid lesions. |
Last Update：2024-04-10 22:29:15
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Product Name: N-benzyl-4-chloro-N-cyclohexylbenzaMide Visit Supplier Webpage Request for quotationCAS: 945714-67-0
Tel: 18301782025
Email: 3008007409@qq.com
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Spot supply
Product Name: N-benzyl-4-chloro-N-cyclohexylbenzaMide Visit Supplier Webpage Request for quotationCAS: 945714-67-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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