FRAXINELLONE
fraxinellone
CAS: 28808-62-0
Molecular Formula: C14H16O3
FRAXINELLONE - Names and Identifiers
FRAXINELLONE - Physico-chemical Properties
| Molecular Formula | C14H16O3 |
| Molar Mass | 232.27 |
| Density | 1.1649 (rough estimate) |
| Melting Point | 114.0 to 118.0 °C |
| Boling Point | 314.44°C (rough estimate) |
| Specific Rotation(α) | (EtOH)-44 |
| Flash Point | 179.3°C |
| Solubility | Easily soluble in chloroform and ethyl acetate. |
| Vapor Presure | 9.29E-06mmHg at 25°C |
| Appearance | Colorless needle crystal |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.5557 (estimate) |
| MDL | MFCD11101451 |
| Physical and Chemical Properties | 化学性质 白色结晶粉末，易溶于氯仿、乙酸乙酯，来源于白鲜皮，白柳(Salix alba L.)的皮。 |
| Use | Uses tryptanthrin is an insecticide that inhibits larval growth and is used for the treatment and protection of crops and agricultural products. Also, it is a natural compound that can be used to treat tumors. |
| In vitro study | Fraxinellone (0-100 μM；12 hours) decreases the percent of PD-L1 positive cells from 20.4% to 11.4% in A549 cells. Cell Viability Assay Cell Line: A549 cells Concentration: 0 μM, 10 μM, 30 μM, 100 μM Incubation Time: 12 hours Result: Inhibited the percent of PD-L1 positive cells. |
| In vivo study | Fraxinellone (oral gavage; 30 and 100 mg/kg; every three days; 30 days) significantly suppresses tumor growth, reduces HIF-1α, pTyr705 STAT3, PD-L1 and VEGF staining compared with the control group in female athymic BALB/c nude mice. Animal Model: BALB/c nude mice Dosage: 30 and 100 mg/kg Administration: Oral gavage; 30 and 100 mg/kg; every three days; 30 days Result: Significantly suppressed tumor growth. |
FRAXINELLONE - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 2811 6.1/PG III |
| RTECS | TI3767000 |
| HS Code | 29321900 |
| Hazard Class | 6.1 |
| Packing Group | III |
FRAXINELLONE - Reference
| Reference Show more | 1. Zuorui, Wang Xibin. Effect of fluorenone on LPS-mediated proliferation and migration of MH7A cells [J]. Chinese traditional medicines, 2019, 041(008):1806-1810. 2. [IF = 4.411] Zhixin Wang et al."Rapid Characterization of Chemical Components in Edible room sparsis crispa by UPLC-Orbitrap MS Analysis and Potential Effects on Allergic retinopathy." Molecules. 2019 Jan;24(16):3014 |
FRAXINELLONE - Uses and synthesis methods
biological activity
Fraxinellone were isolated from the root bark of the Brassicaceae plant Dictamnus dasycarpus. Fraxinellone are PD-L1 inhibitors that inhibit HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential for cancer immunity through targeted PD-L1.
in vitro study
Fraxinellone (0-100 μM;12 hours) decreases the percent of PD-L1 positive cells from 20.4% to 11.4% in A549 cells.
Cell Viability Assay
Cell Line: A549 cells
Concentration: 0 μM, 10 μM, 30 μM, 100 μM
Incubation Time: 12 hours
Result: Inhibited the percent of PD-L1 positive cells.
in vivo studies
Fraxinellone (oral gavage; 30 and 100 mg/kg; every three days; 30 days) significantly suppresses tumor growth, reduces HIF-1α, pTyr705 STAT3, PD-L1 and VEGF staining compared with the control group in female athymic BALB/c nude mice.
Animal Model: BALB/c nude mice
Dosage: 30 and 100 mg/kg
Administration: Oral gavage; 30 and 100 mg/kg; every three days; 30 days
Result: Significantly suppressed tumor growth.
use
1. Fraxinone has the functions of protecting liver and killing insects.
2, used for content determination/identification/pharmacological experiment, etc.
Pharmacological effects: anti-fertility effect, anti-platelet aggregation effect, significant vascular relaxation effect. Selective calcium channel blocking effect, and in a voltage-dependent relationship.
Last Update：2024-04-09 20:52:54
FRAXINELLONE - Reference Information
| Use | fluorenone is an insecticide that inhibits larval growth and is used for the treatment and protection of crops and agricultural products. Also, it is a natural compound that can be used to treat tumors. fluorenone has hepatoprotective and insecticidal effects. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: anti-fertility, anti-platelet aggregation, significant vascular relaxation. Selective calcium channel blockade in a voltage-dependent manner. |
| biological activity | Fraxinellone was isolated from the root bark of the brassica plant Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor that inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. By targeting PD-L1, Fraxinellone has the potential for cancer immunity. |
| in vitro study | Fraxinellone (0-100μm; 12 hours) reduce the percentage of PD-L1 positive cells from 20.4% to 11.4% in A549 cells. Cell viabilityassay Cell Line: A549 cells Concentration: 0 μm, 10 μm, 30 μm, 100 μm Incubation Time: 12 hours Result: Inhibited the percentage of PD-L1 positive cells. |
| Cell Line: | A549 cells |
| Concentration: | 0 μM, 10 μM, 30 μM, 100 μM |
| Incubation Time: | 12 hours |
| Result: | Inhibited the percent of PD-L1 positive cells. Significantly suppressed tumor growth. |
| in vivo studies | Fraxinellone (oral gaugan; 30 and 100 mg/kg; every three days; 30 days) significant indications tumor growth, redutions HIF-1α, pTyr705 STAT3, PD-L1 and VEGF staining compared with the control group in female nude BALB/c nude mice. Animal Model: BALB/c nude mice Dosage: 30 and 100 mg/kg Administration: Oral gavage; 30 and 100 mg/kg; every three days; 30 days Result: Significantly suppressed tumor growth. |
| Animal Model: | BALB/c nude mice |
| Dosage: | 30 and 100 mg/kg |
| Administration: | Oral gavage; 30 and 100 mg/kg; every three days; 30 days |
| Chemical properties | white crystalline powder, soluble in chloroform, ethyl acetate, derived from white fresh bark, Salix alba L. Of the skin. |
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: Fraxinellone Visit Supplier Webpage Request for quotationCAS: 28808-62-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Fraxinellone Visit Supplier Webpage Request for quotationCAS: 28808-62-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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