Felbamate
felbamate
CAS: 25451-15-4
Molecular Formula: C11H14N2O4
Felbamate - Names and Identifiers
Felbamate - Physico-chemical Properties
| Molecular Formula | C11H14N2O4 |
| Molar Mass | 238.24 |
| Density | 1.275±0.06 g/cm3(Predicted) |
| Melting Point | 148-1500C |
| Boling Point | 511.9±50.0 °C(Predicted) |
| Flash Point | 9℃ |
| Solubility | alcohol: soluble |
| Vapor Presure | 1.36E-10mmHg at 25°C |
| Appearance | Solid |
| Color | White |
| pKa | 12.99±0.50(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.558 |
| Physical and Chemical Properties | White powder, odorless. The melting point was 151-152 °c. Soluble in dimethyl sulfoxide, 1-methanol -2-pyrrolidone or dimethyl formamide, slightly soluble in methanol, ethanol, acetone, chloroform or water. |
| Use | Antiepileptic drugs |
Felbamate - Risk and Safety
| UN IDs | UN1230 - class 3 - PG 2 - Methanol |
| WGK Germany | 2 |
| RTECS | TZ1070000 |
| HS Code | 2924296000 |
| Toxicity | LD50 i.p. in mice: 4000 mg/kg (Ludwig et al.) |
Felbamate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.197 ml | 20.987 ml | 41.974 ml |
| 5 mM | 0.839 ml | 4.197 ml | 8.395 ml |
| 10 mM | 0.42 ml | 2.099 ml | 4.197 ml |
| 5 mM | 0.084 ml | 0.42 ml | 0.839 ml |
Last Update：2024-01-02 23:10:35
Felbamate - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| biological activity | Felbamate (Felbatol, ADD-03055) is an anticonvulsant used to treat epilepsy. is an NMDAR antagonist. |
| Target | Value |
| NMDAR | 1.8 mM |
| use | new antiepileptic drugs have no side effects of sedation, depression, hostile behavior, weight gain and weakened cognitive ability of other antiepileptic drugs. For patients over 14 years of age who start partial seizures with monotherapy or additional therapy, additional therapy only occurs in children with partial or systemic seizures caused by small seizures. antiepileptic drugs |
| Production method | 50g of diethyl 2-phenylmalonate (I) is reduced with 12g of lithium aluminum hydride in 500ml of anhydrous ether. The obtained 23 g2-phenyl -1, 3-propanediol (II) and 31gN,N-dimethylaniline were dissolved in 100ml of toluene, and at -10°C, the mixture was added to 33g of phosgene in 150ml of anhydrous toluene solution. Then the reaction was maintained at -5-5 ℃ for 20min, then washed with 5% hydrochloric acid and dried with anhydrous sodium sulfate. Then the human ammonia gas is saturated, heated to reflux, and filtered to obtain filaminate. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:49
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