| toxicity | rats acute oral LD50>5000mg/kg, acute percutaneous LD50>2000mg/kg, acute inhalation LC503.3mg/l (4D). Mild irritation to eyes, no irritation to skin. The non-effective dose of subacute feeding test in rats was 200mg/kg. No teratogenic or mutagenic effects were found in animal experiments. Rainbow trout LC50>100mg/L(96h), Daphnia LC500.0044 mg/L(48h), wild duck acute oral LD50> 2000mg/kg, bee exposure LD50> 0.1mg/mouse. |
| production method | oxime Add 15.8g of anhydrous AlCl3 to 50mL of chlorobenzene, and drop a mixture of γ-chlorobutyryl chloride (14.1g) and chlorobenzene (10mL). The reaction was carried out at 25~30 ℃ for 0min. The reactant is poured into ice water, separated, the water layer is extracted with dichloromethane, the oil layer is combined, the water is washed and dried, the low boiling substance is removed, the potassium hydroxide ethanol solution is added, the residual liquid is filtered after cooling, the dichloromethane is added to dilute the residual liquid, the water is washed and dried, the solvent is evaporated, the 110~112 ℃/1.33 × 103Pa fraction is collected under reduced pressure, the yield is 62.1%, the refractive index is n25D1.5686, and cyclopropyl -4-chlorophen. 18.1g of the intermediate product, 11.2g of hydroxylamine hydrochloride, 36mL of pyridine and 40mL of anhydrous ethanol were heated and refluxed for 5 hours, desolated under reduced pressure, and water was added to precipitate white solid. Recrystallization with benzene-petroleum ether mixed solvent to obtain 16.4g of cyclopropyl-4-chlorophenone oxime with a melting point of 79~96 ℃ and a yield of 83.8%. Condensation of condensed cyclopropyl-4-chlorophenone oxime with p-nitrobromobenzyl: reduction of the condensation product to convert the nitro group to the amino group: addition of 2, 6-difluorobenzoyl isocyanate See the synthesis of fluidinamide. It is added with the reduction product to obtain fluorocarbamide. |
