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Fmoc-Asp-OtBu

Fmoc-Asp-OtBu

CAS: 129460-09-9

Molecular Formula: C23H25NO6

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Fmoc-Asp-OtBu - Names and Identifiers

Name Fmoc-Asp-OtBu
Synonyms Fmoc-Asp-OBu
Fmoc-Asp-OBut
Fmoc-Asp-OtBu
1-tert-Butyl N-Fmoc-L-aspartate
Fmoc-L-aspartic acid 1-tert-butyl ester
L-FMOC-ASPARTIC ACID ALPHA-T-BUTYL ESTER
L-Fmoc-Aspartic acid alpha-tert-butyl ester
N-α-Fmoc-L-aspartic acid α-tert butyl ester
L-Fmoc-Aspartic Acid Alpha-Tert-Butyl Ester
N-ALPHA-L-ASPARTIC ACID ALPHA TERT-BUTYL ESTER
NALPHA-9-Fluorenylmethoxycarbonyl-L-aspartic acid ALPHA-tert-butyl ester
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic Acid 1-tert-Butyl Ester
(3S)-4-tert-butoxy-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-oxobutanoic acid (non-preferred name)
CAS 129460-09-9
InChI InChI=1/C23H25NO6/c1-23(2,3)30-21(27)19(12-20(25)26)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,25,26)/t19-/m0/s1
InChIKey VZXQYACYLGRQJU-IBGZPJMESA-N

Fmoc-Asp-OtBu - Physico-chemical Properties

Molecular FormulaC23H25NO6
Molar Mass411.45
Density1.251±0.06 g/cm3(Predicted)
Melting Point90-98°C
Boling Point617.4±55.0 °C(Predicted)
Flash Point327.2°C
Vapor Presure4.21E-16mmHg at 25°C
AppearancePowder
ColorWhite to Almost white
pKa4.08±0.19(Predicted)
Storage ConditionKeep in dark place,Sealed in dry,Room Temperature
Refractive Index1.576
MDLMFCD00065631

Fmoc-Asp-OtBu - Risk and Safety

Safety Description24/25 - Avoid contact with skin and eyes.
WGK GermanyWGK 2 water endanger
HS Code29224999
Hazard ClassIRRITANT

Fmoc-Asp-OtBu - Introduction

Fluorenylmethoxycarbonyl-aspartate-l-tert-butyl ester (Fmoc-Asp(tBu)-OH) is a commonly used protecting group for aspartic acid. The following is a description of its nature, use, formulation and safety information:

Nature:
-Chemical formula: C26H27NO6
-Molecular weight: 449.49g/mol
-Appearance: White crystalline solid
-Melting point: 205-207°C

Use:
- Fmoc-Asp(tBu)-OH is usually used in peptide synthesis in solid phase synthesis as an aspartic acid protecting group.
-It can generate peptide chains by introducing aspartic acid residues into the synthetic peptide sequence by means of solid phase synthesis.

Preparation Method:
- Fmoc-Asp(tBu)-OH can be obtained by reacting isopropyl acetate or sodium hydroxide with Fmoc-Asp(tBu)-OH.

Safety Information:
- Fmoc-Asp(tBu)-OH is widely used in industry and laboratories, and is generally considered to be a relatively safe substance.
-but still need to pay attention to its toxicity and irritation.
-When handling it, wear appropriate protective equipment, such as gloves and goggles, to prevent contact with skin or eyes.
-When storing and handling, it is recommended to keep it in a dry, cool place, away from fire and oxidizing agents.

Please note that the safety of chemicals needs to be treated with caution. Experiments should be carried out in accordance with safe operating guidelines and waste disposal in accordance with relevant regulations.
Last Update:2024-04-10 22:29:15
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CAS: 129460-09-9
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