Fmoc-D-2-Trifluoromethylphe

Fmoc-D-2-Trifluoromethylphe - Names and Identifiers

Name	Fmoc-D-2-Trifluoromethylphe
Synonyms	RARECHEM BK PT 0132 FMOC-D-PHE(2-CF3)-OH FMOC-D-PHE(2-CF 3)-OH FMOC-D-2-TRIFLUOROMETHYLPHE Fmoc-D-2-Trifluoromethylphe FMOC-D-PHE(2-TRIFLUOROMETHYL)-OH FMOC-D-2-TRIFLUOROMETHYLPHENYLALANINE Fmoc-D-2-Trifluoromethylphenylalanine Fmoc-2-Trifluoromethyl-D-phenylalanine FMOC-2-(TRIFLUOROMETHYL)-D-PHENYLALANINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-2TRIFLUOROPHENYLALANINE (R)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID
CAS	352523-15-0
InChI	InChI=1/C25H20F3NO4/c26-25(27,28)21-12-6-1-7-15(21)13-22(23(30)31)29-24(32)33-14-20-18-10-4-2-8-16(18)17-9-3-5-11-19(17)20/h1-12,20,22H,13-14H2,(H,29,32)(H,30,31)/t22-/m1/s1

Fmoc-D-2-Trifluoromethylphe - Physico-chemical Properties

Molecular Formula	C25H20F3NO4
Molar Mass	455.43
Density	1.351±0.06 g/cm3(Predicted)
Boling Point	609.9±55.0 °C(Predicted)
Flash Point	322.7°C
Vapor Presure	9.94E-16mmHg at 25°C
pKa	3?+-.0.11(Predicted)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.587

Fmoc-D-2-Trifluoromethylphe - Risk and Safety

Hazard Symbols	Xi - Irritant
WGK Germany	3
Hazard Class	IRRITANT

Fmoc-D-2-Trifluoromethylphe - Introduction

Fmoc-D-2-Trifluoromethylphe is an amino acid derivative with the following properties:

1. Appearance: usually white to off-white crystalline powder.
2. chemical structure: chemical name is 9-fluorophenylalanine, with a natural D-configuration amino acid with Fmoc protecting group.
3. solubility: soluble in organic solvents (such as dimethyl sulfoxide and dichloromethane), insoluble in water.
4. Stability: Stable in dry environment, but sensitive to light, humidity and high temperature.

Fmoc-D-2-Trifluoromethylphe are mainly used for peptide synthesis in solid phase synthesis and to adjust the properties of drug molecules. It is commonly used in peptide synthesis as a derivative protecting group for arrow labeling, enzyme substrates, peptide antigen synthesis and drug development. Through the synthesis and modification of the molecule, the trifluoromethyl group can be introduced to change the solubility, activity, metabolic stability and other properties of the compound.

The preparation method of the Fmoc-D-2-Trifluoromethylphe is usually completed by chemical synthesis. The preparation process can be simply described as reacting p-trifluoromethylpropiophenone with p-trifluoromethylphenylethanol, then performing a suitable protecting group reaction, and finally removing the protecting group to obtain the target molecule.

Regarding safety information, Fmoc-D-2-Trifluoromethylphe is a chemical reagent and requires careful handling. When in use, wear appropriate protective equipment such as lab gloves and goggles. Avoid inhaling its dust or particles, avoid contact with skin and eyes. Care should be taken to prevent excessive heating or contact with strong oxidants during operation to prevent dangerous reactions. During storage and handling, care should be taken to avoid mixing with acids, alkalis and other harmful substances.

Last Update：2024-04-09 20:02:46