Fmoc-D-Asn(Trt)-OH
Fmoc-D-Asn(Trt)-OH
CAS: 180570-71-2
Molecular Formula: C38H32N2O5
Fmoc-D-Asn(Trt)-OH - Names and Identifiers
| Name | Fmoc-D-Asn(Trt)-OH |
| Synonyms | Fmoc-D-Asn(Trt)-OH N-Fmoc-N'-trityl-D-asparagine N-ALPHA-FMOC-N-BETA-TRITYL-D-ASPARAGINE -(4-methyltrityl)-L-2,4-diaminobutyric acid (9H-Fluoren-9-yl)MethOxy]Carbonyl D-Asn(Trt)-OH N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-N-OMEGA-TRITYL-D-ASPARAGINE N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(triphenylmethyl)-D-asparagine D-Asparagine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-(triphenylmethyl)- (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-(tritylamino)butanoicacid |
| CAS | 180570-71-2 |
| InChI | InChI=1/C38H32N2O5/c39-35(41)24-34(36(42)43)40(37(44)45-25-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)38(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H2,39,41)(H,42,43)/t34-/m1/s1 |
Fmoc-D-Asn(Trt)-OH - Physico-chemical Properties
| Molecular Formula | C38H32N2O5 |
| Molar Mass | 596.67 |
| Density | 1.271±0.06 g/cm3(Predicted) |
| Melting Point | 211-216°C |
| Boling Point | 858.1±65.0 °C(Predicted) |
| Solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Sparingly) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 3.79±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Acid Sensitive |
| Refractive Index | 1.655 |
| MDL | MFCD00151919 |
Fmoc-D-Asn(Trt)-OH - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
Fmoc-D-Asn(Trt)-OH - Introduction
Fmoc-D-Asn(Trt)-OH is an organic compound with the following properties:
1. Chemical properties: Fmoc-D-Asn(Trt)-OH is a white solid, soluble in some organic solvents such as dimethyl sulfoxide (DMSO) and methanol.
2. Use: Fmoc-D-Asn(Trt)-OH is an important reagent used in the field of polymer synthesis and biochemistry. It is commonly used in protecting group strategies in solid phase synthesis to protect amino groups in amino acids or peptide fragments. This protecting group can be removed by hydrofluoric acid under ammonia-alkaline conditions after the synthesis.
3. Preparation method: Fmoc-D-Asn(Trt)-OH preparation method is more complex, generally need to use multi-step reaction. A common synthetic method is to react trityl amine with N-protected D-asparagine, and then perform a deprotection reaction under appropriate conditions to obtain the final product.
4. Safety information: Although Fmoc-D-Asn(Trt)-OH is relatively safe under general experimental conditions, it may cause irritation to the eyes, skin and respiratory tract. Use should follow laboratory practices and use appropriate protective measures such as gloves, goggles and protective clothing. During use and storage, keep away from fire and oxidizing agents, and store in a dry, cool place.
1. Chemical properties: Fmoc-D-Asn(Trt)-OH is a white solid, soluble in some organic solvents such as dimethyl sulfoxide (DMSO) and methanol.
2. Use: Fmoc-D-Asn(Trt)-OH is an important reagent used in the field of polymer synthesis and biochemistry. It is commonly used in protecting group strategies in solid phase synthesis to protect amino groups in amino acids or peptide fragments. This protecting group can be removed by hydrofluoric acid under ammonia-alkaline conditions after the synthesis.
3. Preparation method: Fmoc-D-Asn(Trt)-OH preparation method is more complex, generally need to use multi-step reaction. A common synthetic method is to react trityl amine with N-protected D-asparagine, and then perform a deprotection reaction under appropriate conditions to obtain the final product.
4. Safety information: Although Fmoc-D-Asn(Trt)-OH is relatively safe under general experimental conditions, it may cause irritation to the eyes, skin and respiratory tract. Use should follow laboratory practices and use appropriate protective measures such as gloves, goggles and protective clothing. During use and storage, keep away from fire and oxidizing agents, and store in a dry, cool place.
Last Update：2024-04-09 02:00:43
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