Fmoc-His(Trt)-OPfp
N(alpha)-fmoc-N(im)-trityl-L-histidine pentafluorophe.ester
CAS: 109434-24-4
Molecular Formula: C46H32F5N3O4
Fmoc-His(Trt)-OPfp - Names and Identifiers
| Name | N(alpha)-fmoc-N(im)-trityl-L-histidine pentafluorophe.ester |
| Synonyms | FMOC-HIS(TRT)-OPFP Fmoc-His(Trt)-OPfp FMOC-L-HIS(TRT)-OPFP FMOC-HIS(T-TRT)-OPFP FMOC-HIS(1-TRT)-OPFP FMOC-HISTIDINE(1-TRT)-OPFP -Trityl-L-histidine pentafluorophenyl ester N-Fmoc-N'-Trityl-L-histidine pentafluorophenyl ester FMOC-N-IM-TRITYL-L-HISTIDINE PENTAFLUOROPHENYL ESTER N(alpha)-fmoc-N(im)-trityl-L-histidine pentafluorophe.ester (2,3,4,5,6-pentafluorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoate 2,3,4,5,6-pentafluorophenyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoate |
| CAS | 109434-24-4 |
| InChI | InChI=1/C46H32F5N3O4/c47-38-39(48)41(50)43(42(51)40(38)49)58-44(55)37(53-45(56)57-26-36-34-22-12-10-20-32(34)33-21-11-13-23-35(33)36)24-31-25-54(27-52-31)46(28-14-4-1-5-15-28,29-16-6-2-7-17-29)30-18-8-3-9-19-30/h1-23,25,27,36-37H,24,26H2,(H,53,56)/t37-/m0/s1 |
Fmoc-His(Trt)-OPfp - Physico-chemical Properties
| Molecular Formula | C46H32F5N3O4 |
| Molar Mass | 785.76 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Melting Point | 97～100℃ |
| Boling Point | 857.8±65.0 °C(Predicted) |
| Flash Point | 472.6°C |
| Vapor Presure | 9.03E-30mmHg at 25°C |
| pKa | 9.90±0.46(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.624 |
Fmoc-His(Trt)-OPfp - Risk and Safety
| WGK Germany | 3 |
Fmoc-His(Trt)-OPfp - Introduction
N-Fmoc-N '-Trityl-L-histidine pentafluorophenyl ester is an organic synthetic reagent. The following is an introduction to some of its properties, uses, methods and safety information:
1. nature:
-Chemical formula: C≡≡H₂ F≡N≡O₂
-Molecular weight: 642.62g/mol
-Appearance: White to yellowish powder
-Melting point: 137-140°C
-Soluble: Soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane
-Stability: Stable at room temperature
2. use:
- N-Fmoc-N '-trityl-L-histidine pentafluorophenyl ester is commonly used in solid phase synthesis in protein chemical synthesis.
-It is a commonly used amino acid protecting group, which can protect the amino functional group in L-histidine and play a protective role in the synthesis.
-When synthesizing peptide fragments or polypeptide chains, it can prevent unintentional side reactions from occurring and protect the process of chemical synthesis.
3. Preparation method:
- N-Fmoc-N '-trityl-L-histidine pentafluorophenyl ester can be obtained by chemical synthesis.
-It usually consists of the reaction of L-histidine with pentafluorophenyl fluorobenzoate in an appropriate solvent.
4. Safety Information:
- N-Fmoc-N '-trityl-L-histidine pentafluorophenyl ester is generally a relatively safe organic compound.
-However, like other chemical reagents, they should be handled with caution and follow appropriate laboratory safety procedures.
-Maintain reagent integrity, avoid contact with skin, eyes and respiratory tract, and avoid ingestion or ingestion.
-During use, pay attention to proper ventilation conditions and wear laboratory safety gloves, goggles and protective clothing.
1. nature:
-Chemical formula: C≡≡H₂ F≡N≡O₂
-Molecular weight: 642.62g/mol
-Appearance: White to yellowish powder
-Melting point: 137-140°C
-Soluble: Soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane
-Stability: Stable at room temperature
2. use:
- N-Fmoc-N '-trityl-L-histidine pentafluorophenyl ester is commonly used in solid phase synthesis in protein chemical synthesis.
-It is a commonly used amino acid protecting group, which can protect the amino functional group in L-histidine and play a protective role in the synthesis.
-When synthesizing peptide fragments or polypeptide chains, it can prevent unintentional side reactions from occurring and protect the process of chemical synthesis.
3. Preparation method:
- N-Fmoc-N '-trityl-L-histidine pentafluorophenyl ester can be obtained by chemical synthesis.
-It usually consists of the reaction of L-histidine with pentafluorophenyl fluorobenzoate in an appropriate solvent.
4. Safety Information:
- N-Fmoc-N '-trityl-L-histidine pentafluorophenyl ester is generally a relatively safe organic compound.
-However, like other chemical reagents, they should be handled with caution and follow appropriate laboratory safety procedures.
-Maintain reagent integrity, avoid contact with skin, eyes and respiratory tract, and avoid ingestion or ingestion.
-During use, pay attention to proper ventilation conditions and wear laboratory safety gloves, goggles and protective clothing.
Last Update：2024-04-10 22:29:15
