Fmoc-L-3-(4-Thiazolyl)-alanine
(S)-N-FMOC-4-Thiazoylalanine
CAS: 205528-32-1
Molecular Formula: C21H18N2O4S
Fmoc-L-3-(4-Thiazolyl)-alanine - Names and Identifiers
| Name | (S)-N-FMOC-4-Thiazoylalanine |
| Synonyms | FMOC-ALA(4-THZ)-OH FMOC-ALA(4-THIAZOYL)-OH FMOC-ALA(4-THIAZOLYL)-OH Fmoc-L-4-Thiazoylalanine FMOC-L-4-THIAZOLYLALANINE Fmoc-L-4-Thiazolylalanine (S)-N-FMOC-4-Thiazoylalanine Fmoc-3-(4-Thiazolyl)-Alanine Fmoc-3-(4-Thiazolyl)-L-alanine Fmoc-L-3-(4-Thiazolyl)-alanine FMOC-3-(4-THIAZOLYL)-L-ALANINE (S)-N-fmoc-4-Thiazoylalanine(e.e.) |
| CAS | 205528-32-1 |
| InChI | InChI=1/C21H18N2O4S/c24-20(25)19(9-13-11-28-12-22-13)23-21(26)27-10-18-16-7-3-1-5-14(16)15-6-2-4-8-17(15)18/h1-8,11-12,18-19H,9-10H2,(H,23,26)(H,24,25)/t19-/m0/s1 |
Fmoc-L-3-(4-Thiazolyl)-alanine - Physico-chemical Properties
| Molecular Formula | C21H18N2O4S |
| Molar Mass | 394.44 |
| Density | 1.378±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 178.2 °C |
| Boling Point | 647.5±55.0 °C(Predicted) |
| Flash Point | 345.4°C |
| Vapor Presure | 1.19E-17mmHg at 25°C |
| Appearance | White powder |
| pKa | 3.42±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.6930 (estimate) |
Fmoc-L-3-(4-Thiazolyl)-alanine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29342000 |
Fmoc-L-3-(4-Thiazolyl)-alanine - Introduction
(S)-N-FMOC-4-Thiazoylalanine is an amino acid derivative with the following properties:
1. Nature:(S)-N-FMOC-4-Thiazoylalanine is a white or white crystal, room temperature is solid. It has good solubility in organic solvents. It is a very stable compound that can be stored and handled under regular experimental conditions.
2. Uses:(S)-N-FMOC-4-Thiazoylalanine peptide synthesis commonly used in solid phase synthesis. Its introduction can increase the diversity of synthetic peptides and provide a means to facilitate functionalization in subsequent steps. In addition, it can also be used in pharmaceutical research, biological research and medical chemistry.
3. Preparation method:(S)-The preparation of N-FMOC-4-Thiazoylalanine is usually completed by chemical synthesis. The specific steps include reacting alanine with 4-thiazolyl acetic anhydride under basic conditions to produce the target product. Finally, the protecting group in the reactant is removed by deprotection reaction to obtain the final product.
4. Safety Information:(S)-The N-FMOC-4-Thiazoylalanine is relatively safe under general operating conditions. However, as with all chemicals, appropriate safety precautions should be taken during handling, including the wearing of appropriate protective gloves, goggles and laboratory coats. In addition, good laboratory safety practices should be followed for any chemical, including this compound, and stored properly.
1. Nature:(S)-N-FMOC-4-Thiazoylalanine is a white or white crystal, room temperature is solid. It has good solubility in organic solvents. It is a very stable compound that can be stored and handled under regular experimental conditions.
2. Uses:(S)-N-FMOC-4-Thiazoylalanine peptide synthesis commonly used in solid phase synthesis. Its introduction can increase the diversity of synthetic peptides and provide a means to facilitate functionalization in subsequent steps. In addition, it can also be used in pharmaceutical research, biological research and medical chemistry.
3. Preparation method:(S)-The preparation of N-FMOC-4-Thiazoylalanine is usually completed by chemical synthesis. The specific steps include reacting alanine with 4-thiazolyl acetic anhydride under basic conditions to produce the target product. Finally, the protecting group in the reactant is removed by deprotection reaction to obtain the final product.
4. Safety Information:(S)-The N-FMOC-4-Thiazoylalanine is relatively safe under general operating conditions. However, as with all chemicals, appropriate safety precautions should be taken during handling, including the wearing of appropriate protective gloves, goggles and laboratory coats. In addition, good laboratory safety practices should be followed for any chemical, including this compound, and stored properly.
Last Update：2024-04-09 21:00:56
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