Fmoc-L-Cys(Mob)-OH
N(alpha)-fmoc-S-(4-methoxybenzyl)-L-cysteine
CAS: 141892-41-3
Molecular Formula: C26H25NO5S
Fmoc-L-Cys(Mob)-OH - Names and Identifiers
| Name | N(alpha)-fmoc-S-(4-methoxybenzyl)-L-cysteine |
| Synonyms | Fmoc-BOH Fmoc-Cys(Mob)-OH Fmoc-L-Cys(Mob)-OH Fmoc-Cys(pMeOBzl)-OH Fmoc-Cys(4-MeO-Bzl)-OH Fmoc-S-4-methoxybenzyl-L-cysteine N-FMOC-S-(4-METHOXYBENZYL)-L-CYSTEINE N-Fmoc-S-(4-Methoxybenzyl)-L-Cysteine N-ALPHA-FMOC-S-P-METHOXYBENZYL-L-CYSTEINE N-ALPHA-FMOC-S-(4-METHOXYBENZYL)-L-CYSTEINE N(alpha)-fmoc-S-(4-methoxybenzyl)-L-cysteine NALPHA-9-Fluorenylmethoxycarbonyl-S-(4-methoxybenzyl)-L-cysteine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-S-P-METHOXYBENZYL-L-CYSTEINE N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(4-methoxybenzyl)-L-cysteine N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-S-(4-METHOXYBENZYL)-L-CYSTEINE |
| CAS | 141892-41-3 |
| InChI | InChI=1/C26H25NO5S/c1-31-18-12-10-17(11-13-18)15-33-16-24(25(28)29)27-26(30)32-14-23-21-8-4-2-6-19(21)20-7-3-5-9-22(20)23/h2-13,23-24H,14-16H2,1H3,(H,27,30)(H,28,29)/t24-/m0/s1 |
Fmoc-L-Cys(Mob)-OH - Physico-chemical Properties
| Molecular Formula | C26H25NO5S |
| Molar Mass | 463.55 |
| Density | 1.295±0.06 g/cm3(Predicted) |
| Melting Point | ~140°C |
| Boling Point | 689.5±55.0 °C(Predicted) |
| Specific Rotation(α) | -35 º (c=1% in methanol) |
| Flash Point | 370.8°C |
| Vapor Presure | 5.82E-20mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| pKa | 3.45±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.632 |
| MDL | MFCD00065635 |
Fmoc-L-Cys(Mob)-OH - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29224999 |
Fmoc-L-Cys(Mob)-OH - Introduction
N-Fmoc-S-(4-Methoxybenzyl)-L-cysteine is an organic compound with the following properties:
1. Appearance: white solid.
2. melting point: about 180-185 degrees Celsius.
3. Solubility: Good solubility in organic solvents, such as dimethylformamide and dichloromethane.
The main use of N-Fmoc-S-(4-methoxybenzyl)-L-cysteine is as a protecting group for synthetic peptides in the fields of biochemistry and medicinal chemistry. It can protect the sulfur atom in the side chain of cysteine for selective reaction during peptide synthesis. In addition, the compound can also be used for the synthesis of biologically active peptide fragments.
The method of preparing N-Fmoc-S-(4-methoxybenzyl)-L-cysteine includes the following steps:
1. Combine L-cysteine and N-methyl dimethylformamide to obtain N-methyl cysteine by acid-catalyzed reaction.
2. 4-Methoxybenzyl alcohol and carbodiimide are added and etherification reaction is carried out to produce N-(4-methoxybenzyl)-L-cysteine.
3. Using Fmoc-OSu as the reaction reagent, the target product N-Fmoc-S-(4-methoxybenzyl)-L-cysteine was obtained by acylation reaction.
Regarding the safety information of this compound, the following should be noted:
1. The compound may be potentially toxic and irritating, and direct contact with skin and eyes should be avoided.
2. in handling and storage, should take appropriate safety measures, such as wearing protective gloves, glasses and laboratory coats.
3. Follow proper laboratory procedures and avoid inhaling its powder or solution.
4. Waste should be disposed of as organic waste in accordance with local regulations.
1. Appearance: white solid.
2. melting point: about 180-185 degrees Celsius.
3. Solubility: Good solubility in organic solvents, such as dimethylformamide and dichloromethane.
The main use of N-Fmoc-S-(4-methoxybenzyl)-L-cysteine is as a protecting group for synthetic peptides in the fields of biochemistry and medicinal chemistry. It can protect the sulfur atom in the side chain of cysteine for selective reaction during peptide synthesis. In addition, the compound can also be used for the synthesis of biologically active peptide fragments.
The method of preparing N-Fmoc-S-(4-methoxybenzyl)-L-cysteine includes the following steps:
1. Combine L-cysteine and N-methyl dimethylformamide to obtain N-methyl cysteine by acid-catalyzed reaction.
2. 4-Methoxybenzyl alcohol and carbodiimide are added and etherification reaction is carried out to produce N-(4-methoxybenzyl)-L-cysteine.
3. Using Fmoc-OSu as the reaction reagent, the target product N-Fmoc-S-(4-methoxybenzyl)-L-cysteine was obtained by acylation reaction.
Regarding the safety information of this compound, the following should be noted:
1. The compound may be potentially toxic and irritating, and direct contact with skin and eyes should be avoided.
2. in handling and storage, should take appropriate safety measures, such as wearing protective gloves, glasses and laboratory coats.
3. Follow proper laboratory procedures and avoid inhaling its powder or solution.
4. Waste should be disposed of as organic waste in accordance with local regulations.
Last Update：2024-04-09 21:54:55
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CAS: 141892-41-3
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