Fmoc-L-histidine
Fmoc-His-OH
CAS: 116611-64-4
Molecular Formula: C21H19N3O4
Fmoc-L-histidine - Names and Identifiers
Fmoc-L-histidine - Physico-chemical Properties
| Molecular Formula | C21H19N3O4 |
| Molar Mass | 377.39 |
| Density | 1.372±0.06 g/cm3(Predicted) |
| Melting Point | 171-174 °C(Solv: methanol (67-56-1); water (7732-18-5)) |
| Boling Point | 706.7±60.0 °C(Predicted) |
| Solubility | DMSO (Slightly), DMF (Slightly, Sonicated), Methanol (Very Slightly, Heated) |
| Appearance | Solid |
| Color | White |
| pKa | 3.26±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
Fmoc-L-histidine - Risk and Safety
| HS Code | 29332900 |
Fmoc-L-histidine - Introduction
N-Fmoc-L-Histidine, whose chemical name is N-[9-fluoromethyl-9-(oxodimethyl) propoxy] hydroxybutyryl-L-histidine, is an amino acid protecting group. Its properties are solid, white or off-white crystalline powder, molecular formula is C20H22FN3O5, relative molecular mass is 413.41.
N-Fmoc-L-histidine is commonly used in peptide synthesis reactions as a reagent to protect amino acid groups. It can be modified at specific positions in chemical synthesis by protecting the amino group of histidine. Because the amino group of N-Fmoc-L-histidine is protected, unnecessary reactions do not occur under the reaction conditions, ensuring selectivity and efficiency.
The preparation method of N-Fmoc-L-histidine is generally obtained by reacting L-histidine with 9-fluoromethyl-9-(oxodimethyl) propoxy. Suitable separation techniques, such as crystallization, cold precipitation, etc., are then employed to obtain the desired product. The preparation process requires attention to the operating conditions and the purity of the reaction material.
Regarding safety information, N-Fmoc-L-histidine is a chemical reagent that requires compliance with routine laboratory safety practices. Its specific safety information can refer to the relevant safety data sheet (MSDS). During use, care should be taken to prevent inhalation, contact with skin and eyes, and avoid ingestion. Wear appropriate personal protective equipment such as lab gloves, goggles and lab coats when using. In the event of an accident, rinse immediately with plenty of water and seek medical treatment. When handling or disposing of waste, local regulations shall be followed.
N-Fmoc-L-histidine is commonly used in peptide synthesis reactions as a reagent to protect amino acid groups. It can be modified at specific positions in chemical synthesis by protecting the amino group of histidine. Because the amino group of N-Fmoc-L-histidine is protected, unnecessary reactions do not occur under the reaction conditions, ensuring selectivity and efficiency.
The preparation method of N-Fmoc-L-histidine is generally obtained by reacting L-histidine with 9-fluoromethyl-9-(oxodimethyl) propoxy. Suitable separation techniques, such as crystallization, cold precipitation, etc., are then employed to obtain the desired product. The preparation process requires attention to the operating conditions and the purity of the reaction material.
Regarding safety information, N-Fmoc-L-histidine is a chemical reagent that requires compliance with routine laboratory safety practices. Its specific safety information can refer to the relevant safety data sheet (MSDS). During use, care should be taken to prevent inhalation, contact with skin and eyes, and avoid ingestion. Wear appropriate personal protective equipment such as lab gloves, goggles and lab coats when using. In the event of an accident, rinse immediately with plenty of water and seek medical treatment. When handling or disposing of waste, local regulations shall be followed.
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: Semaglutide Impurity 18 Visit Supplier Webpage Request for quotationCAS: 116611-64-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: FMOC-HIS-OH Visit Supplier Webpage Request for quotationCAS: 116611-64-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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