Fmoc-Orn(Boc)-OH
N(alpha)-fmoc-N(delta)-boc-L-ornithine
CAS: 109425-55-0
Molecular Formula: C25H30N2O6
Fmoc-Orn(Boc)-OH - Names and Identifiers
| Name | N(alpha)-fmoc-N(delta)-boc-L-ornithine |
| Synonyms | Fmoc-Orn(Boc)-OH RARECHEM EM WB 0176 Nalpha-Fmoc-Ndelta-Boc-L-ornithine N(α)-fmoc-N(delta)-boc-L-ornithine N-DELTA-BOC-N-ALPHA-FMOC-L-ORNITHINE N-ALPHA-FMOC-N-DELTA-BOC-L-ORNITHINE N-ALPHA-FMOC-N-DELTA-T-BOC-L-ORNITHINE N(alpha)-fmoc-N(delta)-boc-L-ornithine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-DELTA-T-BUTOXYCARBONYL-L-ORNITHINE N-alpha-(9-fluorenylmethyloxycarbonyl)-N-delta-t-butyl-oxycarbonyl-L-ornithine N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-GAMMA-T-BUTYL-OXYCARBONYL-L-ORNITHINE N~5~-(tert-butoxycarbonyl)-N~2~-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-ornithine N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-DELTA-TERT-BUTYLOXYCARBONYL-L-ORNITHINE |
| CAS | 109425-55-0 |
| InChI | InChI=1/C25H30N2O6/c1-25(2,3)33-23(30)26-14-8-13-21(22(28)29)27-24(31)32-15-20-18-11-6-4-9-16(18)17-10-5-7-12-19(17)20/h4-7,9-12,20-21H,8,13-15H2,1-3H3,(H,26,30)(H,27,31)(H,28,29)/t21-/m0/s1 |
Fmoc-Orn(Boc)-OH - Physico-chemical Properties
| Molecular Formula | C25H30N2O6 |
| Molar Mass | 454.52 |
| Density | 1.226±0.06 g/cm3(Predicted) |
| Melting Point | 111-115℃ |
| Boling Point | 679.0±55.0 °C(Predicted) |
| Flash Point | 364.5°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 2.28E-19mmHg at 25°C |
| Appearance | Powder |
| Color | White to Almost white |
| BRN | 4772025 |
| pKa | 3.85±0.21(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.57 |
| MDL | MFCD00065668 |
Fmoc-Orn(Boc)-OH - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
Fmoc-Orn(Boc)-OH - Introduction
N-Fmoc-N '-Boc-L-ornithine is an amino acid protecting group with the following properties:
1. Properties: N-Fmoc-N '-Boc-L-ornithine is a white crystalline solid with high thermal stability. It can be stable under strong acid and alkali conditions, but for reagents with strong reducing properties, such as cyanide, it may be reduced.
2. use: N-Fmoc-N '-Boc-L-ornithine commonly used in peptide synthesis field. The presence of its protecting group can protect the active group of ornithine during the synthesis to prevent unwanted reactions with other reactants. Once the synthesis is complete, the protecting group can be removed by appropriate reaction conditions to restore ornithine activity.
3. preparation method: N-Fmoc-N '-Boc-L-ornithine can generally be prepared by chemical synthesis. First, ornithine is reacted with Fmoc-Cl (fluoroformimide) to produce N-Fmoc-L-ornithine. Then, a protection reaction is performed using Boc-OSu (a successful contraction deprotecting agent) to react with N-Fmoc-L-ornithine to form the N-Fmoc-N '-Boc-L-ornithine.
4. Safety information: N-Fmoc-N '-Boc-L-ornithine should be stored properly, avoid exposure to air or high humidity environment, to prevent its decomposition or hydrolysis. During the operation, it is necessary to strictly observe the safe operation of the chemical laboratory, such as wearing appropriate protective equipment (gloves, goggles, etc.). In addition, care should be taken to avoid contact with strong reducing reagents to avoid accidental reactions. For specific safe handling of chemicals, refer to the relevant Safety Data Sheet (SDS) for details.
1. Properties: N-Fmoc-N '-Boc-L-ornithine is a white crystalline solid with high thermal stability. It can be stable under strong acid and alkali conditions, but for reagents with strong reducing properties, such as cyanide, it may be reduced.
2. use: N-Fmoc-N '-Boc-L-ornithine commonly used in peptide synthesis field. The presence of its protecting group can protect the active group of ornithine during the synthesis to prevent unwanted reactions with other reactants. Once the synthesis is complete, the protecting group can be removed by appropriate reaction conditions to restore ornithine activity.
3. preparation method: N-Fmoc-N '-Boc-L-ornithine can generally be prepared by chemical synthesis. First, ornithine is reacted with Fmoc-Cl (fluoroformimide) to produce N-Fmoc-L-ornithine. Then, a protection reaction is performed using Boc-OSu (a successful contraction deprotecting agent) to react with N-Fmoc-L-ornithine to form the N-Fmoc-N '-Boc-L-ornithine.
4. Safety information: N-Fmoc-N '-Boc-L-ornithine should be stored properly, avoid exposure to air or high humidity environment, to prevent its decomposition or hydrolysis. During the operation, it is necessary to strictly observe the safe operation of the chemical laboratory, such as wearing appropriate protective equipment (gloves, goggles, etc.). In addition, care should be taken to avoid contact with strong reducing reagents to avoid accidental reactions. For specific safe handling of chemicals, refer to the relevant Safety Data Sheet (SDS) for details.
Last Update：2024-04-09 21:01:54
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