Fradafiban

Name	Fradafiban
Synonyms	BIBU-52 Fradafiban 3-Pyrrolidineacetic acid, 5-[[[4'-(aminoiminomethyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-2-oxo-, (3S,5S)-
CAS	148396-36-5

Molecular Formula	C20H21N3O4
Molar Mass	367.403
Density	1.38±0.1 g/cm3(Predicted)
pKa	4.29±0.10(Predicted)
In vitro study	Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a K d value of 148 nM.
In vivo study	Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion.

biological activity	Fradafiban is a non-peptide platelet glycoprotein IIb/IIIa complex antagonist, it binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.
Target	Kd: 148 nM (human platelet GP IIb/IIIa complex)

Last Update：2024-04-09 21:11:58

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CAS: 148396-36-5
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Mobile: 18021002903
QQ: 3008007409

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Fradafiban

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