Molecular Formula | C15H20O |
Molar Mass | 216.32 |
Density | 0.945±0.06 g/cm3(Predicted) |
Melting Point | 74-75 °C |
Boling Point | 309.6±11.0 °C(Predicted) |
Storage Condition | 2-8℃ |
Reference Show more | 1. [IF=6.057] Weijia Zhou et al."On-line comprehensive two-dimensional liquid chromatography tandem mass spectrometry for the analysis of Curcuma kwangsiensis."Talanta. 2018 Aug;186:73 2. [IF=2.727] Shen Song et al."Spectrum-effect relationship analysis by binary chromatographic fingerprint to identify components responsible for the antibacterial activity of the essential oil from Curcumae wenyujin."Int J Food Prop. 2018;21(1):546-556 3. [IF=3.205] Jie Tang et al."Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."J Chromatogr B. 2021 Aug;1179:122827 4. [IF=7.658] Mingyue Zhou et al."Atomic zinc sites with hierarchical porous carbon for high-throughput chemical screening with high loading capacity and stability."Pharmacol Res. 2022 Mar;:106154 |
biological activity | furan dicarboxylic acid has a strong inhibitory and killing effect on a variety of tumor cells cultured in vitro, including acute promyelocytic leukemia cells HL-60, chronic myeloid leukemia K562, gastric adenocarcinoma cells SGC-7901, prostate cancer cells PC3, breast duct cancer cells MDA-MB-435S, liver cancer cells SMMC-7721, liver cancer cells HepG2, lung adenocarcinoma cells A549, human laryngeal epidermoid carcinoma Hep-2, human fibrosarcoma cell HT-1080 and other tumor cell apoptosis-inducing effect, the IC50 value of 0.98-4.81 μg/ml. |
Application | furan Diene has a broad spectrum of anti-tumor cell proliferation in vitro, the normal rat bone marrow cells did not show obvious side effects, so it is considered that furadiene has further research value, and its anti-tumor mechanism also needs further research and discussion. The pharmacological activity of furan Diene, its analgesic effect and antibacterial, antiviral effect; Liver protective effect and anti-inflammatory effect. |