Molecular Formula | C8H7N3O5 |
Molar Mass | 225.16 |
Density | 1.5406 (rough estimate) |
Melting Point | 254-256°C (dec.) |
Boling Point | 366.66°C (rough estimate) |
Flash Point | 2 °C |
Water Solubility | 极微溶于氯仿、水、乙醇和四氯化碳,1L水中溶40mg该品。稍溶于二甲基甲酰胺。 |
Solubility | Soluble in chloroform, water, ethanol and carbon tetrachloride, 11g of water soluble 40mg of the product. Slightly soluble in dimethylformamide. |
Vapor Presure | 3.59E-05mmHg at 25°C |
Appearance | Pale yellow crystalline powder |
Color | yellow |
Maximum wavelength(λmax) | ['365nm(DMSO)(lit.)'] |
Merck | 14,4300 |
BRN | 8317414 |
pKa | -1.98±0.20(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
Sensitive | Light Sensitive |
Refractive Index | 1.7180 (estimate) |
MDL | MFCD00010550 |
Physical and Chemical Properties | Light yellow crystalline powder, odorless, bitter. Melting point 275 °c (decomposition). Insoluble in water, ethanol, slightly soluble in chloroform, slightly soluble in dimethylformamide. Mouse oral LD501.5-4.54g/kg. |
Use | The product is a broad antibacterial spectrum of fungicides. As an anti-infective drug, it is effective against a variety of gram-positive and negative Escherichia coli, Bacillus anthracis, paratyphoid Bacillus, etc., for the treatment of bacillary dysentery, enteritis, also for vaginal infection, in recent years for the treatment of typhoid fever, the curative effect is good. As an additive for animal drugs and beverages, it has a special effect on salmonella, such as chicken White dysentery and Escherichia coli |
Risk Codes | R62 - Possible risk of impaired fertility R40 - Limited evidence of a carcinogenic effect R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R68 - Possible risk of irreversible effects |
Safety Description | S36 - Wear suitable protective clothing. S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
WGK Germany | 3 |
RTECS | RQ3675000 |
TSCA | Yes |
HS Code | 29349990 |
Raw Materials | Acetic anhydride 2-Furaldehyde Urea Ethanolamine |
Reference Show more | 1. Yu Hao, Wang Tingting, hechunxiang, etc. Electrocatalytic reduction of furazolidone by Poly (O-aminophenol) functional membrane [J]. Journal of Science of Normal University, 2017(1). 2. Liang Jinling, Tang Ke, Huang Yuxia et al. Molecular Simulation and verification of furacilin Molecularly Imprinted Polymer [J]. Computer and applied chemistry 2018(5). |
Furazolidone (Furazolidone, once named Furazolidone) is a nitrofuran antibiotics, can be used to treat bacteria and protozoa caused by dysentery, enteritis, gastric ulcer and other gastrointestinal diseases. Furazolidone is a broad-spectrum antibacterial drug, which has inhibitory effect on common gram-negative and positive bacteria. The People's Republic of China, the Ministry of Agriculture listed furazolidone as a prohibited drug, not detected in animal foods. The FDA also banned the use of nitrofurans, including furazolidone, in animal-based foods in 2002. Generally should not be used for patients with ulcer disease or bronchial asthma. Alcohol consumption during oral administration of this product can cause disulfiram-like reactions, manifested as skin flushing, itching, Fever, Head Pain, Nausea, Abdominal Pain, tachycardia, elevated blood pressure, chest tightness, irritability, etc, therefore, alcohol use was prohibited during the treatment and within 5 days after drug withdrawal.
light yellow crystalline powder, odorless, bitter. Insoluble in water and ethanol, slightly soluble in chloroform, slightly soluble in dimethylamide.
The furazolidone was obtained by condensation of ethanolamine with urea, nitrosation with sodium nitrite, cyclization, and finally reduction with iron powder and condensation with 5-nitro-2-furfuryl glycol diacetate and formaldehyde.
This product is 3-[[(5-nitro-2-furyl) methylene] amino]-2-oxazolidinone. The content of C8H7N305 shall be between 97.0% and 103.0% based on the dry product.
melting point 254-256°C (dec.)
Storage Conditions 0-6°C
Merck 13,4321
Stable. Combustion. Compatible with strong oxidizing agents.
NIST chemical substance information Furazolidone(67-45-8)
EPA chemical substance information 2-Oxazolidinone, 3-[[(5-nitro-2-furanyl)methylene] amino]-(67-45-8)
nitrofuran antibacterial drugs. The antibacterial spectrum was similar to that of furanoidine. Its mechanism of action is to interfere with bacterial oxidoreductase, thereby blocking the normal metabolism of bacteria. It has antibacterial effect on Salmonella, Shigella, Escherichia coli, Proteus, streptococcus and Staphylococcus. Bacteria resistant to the product is not easy to produce resistance, and there is no cross resistance to sulfonamides and antibiotics. Mainly used for bacillary dysentery, enteritis, typhoid, paratyphoid and external treatment of vaginal trichomoniasis.
furazolidone is what we usually call furazolidone, is a nitrofuran antibacterial drugs, gram-positive and negative bacteria have a certain antibacterial effect, including Salmonella, Shigella, escherichia coli, Pneumonia Klebsiella, Enterobacter, Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, Vibrio cholerae, Campylobacter, Bacteroides, etc, giardia is also active. Its mechanism of action is to interfere with bacterial oxidoreductases and thereby block the normal metabolism of the bacteria. Mainly used for the treatment of various intestinal infections, bacillary dysentery, Diarrhea, enteritis, colibacillosis septicemia, typhoid, cholera, Transmissibility rhinitis, blackhead disease, trichomoniasis, it can also be used in combination with drugs such as antacids to treat antral gastritis caused by Helicobacter pylori.
Furazolidone on infants and young children do have side effects, such as liver and kidney damage, allergic reactions, etc., so it is generally recommended to use as little as possible or not.
Take lg of this product, add 100ml of water, shake for 15 minutes, filter, take the filtrate to determine according to law (General rule 0631),pH value should be 5-5~7.0.
take 5g of this product, put it in a 250ml Erlenmeyer flask, add 100ml of ethanol, heat and reflux for 5 minutes, let it cool to 25°C and 2°C, then filter it with a 5# vertical melting funnel, the residue was washed with 50ml of ethanol, the washing liquid was combined with the filtrate, and the residue was placed in a weighed evaporation dish. The ethanol was distilled off, and the residue was dried at 80 ° C. For 1 hour, and the remaining residue should not exceed 0.5%.
operation in the dark. Take about 50mg of this product, precision weighing, 10ml measuring flask, add N, N-dimethylformamide 5ml, put the water bath to dissolve, cool, dilute with acetone to the scale, shake well, as a test solution; Another 5-nitrofurfural diacetate standard amount, plus N, N-dimethylformamide-acetone (1:1) the solution was dissolved and quantitatively diluted to prepare a solution containing 50ug per 1 ml as a control solution. According to the thin layer chromatography (General 0502) test, absorb 20 u1 of each of the above two solutions, respectively point on the same silica gel G thin layer plate, with toluene-dioxane (95:5) as the developing solvent, expand, take out, dry, dry at 105°C for 5 minutes, spray with phenylhydrazine hydrochloride solution (take phenylhydrazine hydrochloride 0.75g, add ethanol 10ml to dissolve, dilute with water to 50ml, decolorize with activated carbon, filter, take the whole filtrate, add hydrochloric acid 25ml, add water to 105 ml), and heat at °C for 5 minutes. For the test solution, if the impurity spot corresponding to the main spot of the reference solution, its color should not be deeper (1.0%) compared with the main spot of the reference solution.
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.2%.
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
operation in the dark. Take about 20mg of this product, precision weighing, 250ml measuring flask, add N,N-dimethylformamide 40ml, shake to dissolve, dilute with water to the scale, shake, precision take 10ml, set it in a 100ml measuring flask, dilute it to the scale with water, shake it well, use it as a test solution, and measure the absorbance at the wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (general rule); another furazolidone reference substance was determined by the same method and calculated.
light yellow crystalline powder, odorless, bitter. Melting point 275 °c (decomposition). Insoluble in water, ethanol, slightly soluble in chloroform, slightly soluble in dimethylformamide. Mouse oral LD501.5-4.54g/kg.
antibacterial drugs.
light shielding, sealed storage.
marking of dangerous goods Xn
Hazard code 62-40
Safety instructions 36-22
WGK Germany 3
RTECS#: RQ3675000
Customs Code 29349990
Toxic Substance Data 67-45-8(Hazardous Substances Data)
This product contains furazolidone (C8H7N305) should be the label amount of 90.0% ~ 110.0%.
This product is yellow tablet or sugar-coated tablet, yellow after removing the coating.
operation in the dark. Take 10 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about equivalent to 20mg of furazolidone), put it in a 250ml measuring flask, add 40ml of dimethylformamide, shake to dissolve furazolidone, dilute to the scale with water, shake, filter, take 10ml of filtrate accurately, put it in a 100ml measuring flask, dilute to the scale with water, shake well, as a test solution, measure absorbance at the wavelength of 367nm according to UV-visible spectrophotometry (General rule 0401); Take another 20mg of furazolidone reference substance, weigh it accurately, put it in a 250ml measuring flask, add N,N-dimethylformamide 40ml, shake to dissolve, dilute to scale with water, shake well, take 10ml accurately, put it in a 100ml measuring flask, dilute to scale with water, shake well, as a reference solution, the same method of determination, calculation, that is.
Same as furazolidone.
(l)10mg (2)30mg (3)100mg
light shielding, sealed storage.
oral, adult 0.1g/time, 3~4 times/day; Children daily 5mg ~ 10mg/kg, divided into 4 times.